Alexey Khodjakov,Conly L Rieder
Alexey Khodjakov
The concept of checkpoint controls revolutionized our understanding of the cell cycle. Here we revisit the defining features of checkpoints and argue that failure to properly appreciate the concept is leading to misinterpretation of experim...
Lena C Hileman,Pilar Cubas
Lena C Hileman
CYCLOIDEA (CYC)-like TCP genes are critical for flower developmental patterning. Exciting recent breakthroughs, including a study by Song et al. published in BMC Evolutionary Biology, demonstrate that CYC-like genes have also had an importa...
Mechanisms of ubiquitin transfer by the anaphase-promoting complex [0.03%]
泛素连接酶Anaphase-Promoting Complex的泛素转移机制研究
Mary E Matyskiela,Monica C Rodrigo-Brenni,David O Morgan
Mary E Matyskiela
The anaphase-promoting complex (APC) is a ubiquitin-protein ligase required for the completion of mitosis in all eukaryotes. Recent mechanistic studies reveal how this remarkable enzyme combines specificity in substrate binding with flexibi...
Keren Vaknin,Amir Goren,Gil Ast
Keren Vaknin
Transposable elements (TEs) have contributed a wide range of functional sequences to their host genomes. A recent paper in BMC Molecular Biology discusses the creation of new transcripts by transposable element insertion upstream of retroco...
Elizabeth R Burton,Steven K Libutti
Elizabeth R Burton
As the tumor vasculature is a key element of the tumor stroma, angiogenesis is the target of many cancer therapies. Recent work published in BMC Cell Biology describes a fusion protein that combines a peptide previously shown to home in on ...
Molecular machines or pleiomorphic ensembles: signaling complexes revisited [0.03%]
分子机器还是多重形态集合体： revisit信号转导复合物
Bruce J Mayer,Michael L Blinov,Leslie M Loew
Bruce J Mayer
Signaling complexes typically consist of highly dynamic molecular ensembles that are challenging to study and to describe accurately. Conventional mechanical descriptions misrepresent this reality and can be actively counterproductive by mi...
Dagmar Ringe,Gregory A Petsko
Dagmar Ringe
Eric Y Chan,Marcus J Korth,Michael G Katze
Eric Y Chan
Recently in BMC Medical Genomics, Tozeren and colleagues have uncovered virus-host interactions by searching for conserved peptide motifs in HIV and human proteins. Their computational model provides a novel perspective in the interpretatio...
Adaptation by introgression [0.03%]
渗入杂交适应性演化
Michael L Arnold,Noland H Martin
Michael L Arnold
Both selective and random processes can affect the outcome of natural hybridization. A recent analysis in BMC Evolutionary Biology of natural hybridization between an introduced and a native salamander reveals the mosaic nature of introgres...
Anthony G Lee
Anthony G Lee
Anionic lipids affect the function of many channels, including connexins, as shown in a recent report in BMC Biology. These effects might follow from direct binding of the anionic lipids to the channels.