The bacterial pathogen Listeria monocytogenes: an emerging model in prokaryotic transcriptomics [0.03%]
单核细胞增生性李斯特菌——原核生物转录组研究的新兴模式微生物
Pascale Cossart,Cristel Archambaud
Pascale Cossart
A major challenge in bacterial pathogenesis is understanding the molecular basis of the switch from saprophytism to virulence. Following a recent whole-genome transcriptomic analysis using tiling arrays, an article published in BMC Genomics...
Forward genetics in Tribolium castaneum: opening new avenues of research in arthropod biology [0.03%]
赤褐拟步甲的正向遗传学：为节肢动物生物学研究开辟新途径
Andrew D Peel
Andrew D Peel
A recent paper in BMC Biology reports the first large-scale insertional mutagenesis screen in a non-drosophilid insect, the red flour beetle Tribolium castaneum. This screen marks the beginning of a non-biased, 'forward genetics' approach t...
Itay Tirosh,Naama Barkai,Kevin J Verstrepen
Itay Tirosh
Evolutionary changes in gene expression are a main driver of phenotypic evolution. In yeast, genes that have rapidly diverged in expression are associated with particular promoter features, including the presence of a TATA box, a nucleosome...
Coordinated gene expression by post-transcriptional regulons in African trypanosomes [0.03%]
非洲锥虫中后转录调控子的协调基因表达
Marc Ouellette,Barbara Papadopoulou
Marc Ouellette
The regulation of gene expression in trypanosomes is unique. In the absence of transcriptional control at the level of initiation, a subset of Trypanosoma brucei genes form post-transcriptional regulons in which mRNAs are co-regulated in re...
Bertrand Garcia-Moreno
Bertrand Garcia-Moreno
Bioinformatics-based searches for correlations between subcellular localization and pI or charge distribution of proteins have failed to detect meaningful correlations. Recent work published in BMC Biology finds that a physicochemical metri...
Miranda Robertson
Miranda Robertson
Editorial
Journal of biology. 2009;8(10):87. DOI:10.1186/jbiol200 2009
Ferenc Müller,Làszlò Tora
Ferenc Müller
The complexity of the core promoter transcription machinery has emerged as an additional level of transcription regulation that is used during vertebrate development. Recent studies, including one published in BMC Biology, provide mechanist...
Life and death as a T lymphocyte: from immune protection to HIV pathogenesis [0.03%]
T淋巴细胞的生与死：从免疫保护到HIV致病机制研究
Nienke Vrisekoop,Judith N Mandl,Ronald N Germain
Nienke Vrisekoop
Detailed analysis of T cell dynamics in humans is challenging and mouse models can be important tools for characterizing T cell dynamic processes. In a paper just published in Journal of Biology, Marques et al. suggest that a mouse model wi...
Generalized immune activation as a direct result of activated CD4+ T cell killing [0.03%]
活化的CD4⁺T细胞杀伤直接导致的广义免疫激活现象
Rute Marques,Adam Williams,Urszula Eksmond et al.
Rute Marques et al.
Background: In addition to progressive CD4(+) T cell immune deficiency, HIV infection is characterized by generalized immune activation, thought to arise from increased microbial exposure resulting from diminishing immuni...
The gene complement of the ancestral bilaterian - was Urbilateria a monster? [0.03%]
祖先双边动物的基因组成--始双侧体是怪兽吗？
David J Miller,Eldon E Ball
David J Miller
Expressed sequence tag analyses of the annelid Pomatoceros lamarckii, recently published in BMC Evolutionary Biology, are consistent with less extensive gene loss in the Lophotrochozoa than in the Ecdysozoa, but it would be premature to gen...