Tailored molecular weight hyaluronic acid production by engineered Lactococcus lactis [0.03%]
通过工程化改造的乳酸链球菌生产定制分子量的透明质酸
Sharath Soundiraraj,Nakul Ravishankar,Pandeeswari Jeeva et al.
Sharath Soundiraraj et al.
Background: Hyaluronic acid (HA) is a glycosaminoglycan with a wide range of biological functions that depend on its molecular weight (MW). Recently, there has been an increasing interest in producing HA at particular MWs...
Engineering a yeast cell factory for high-level production of unnatural ginsenoside 3β-O-Glc-DM [0.03%]
工程化酵母细胞工厂高效生产稀有人参皂苷3-O-Glc-DM
Xiao-Yan Sun,Yu Peng,Ting Gong et al.
Xiao-Yan Sun et al.
A comparative framework of natural nisin variants: linking genetic basis to future bioengineering applications [0.03%]
天然变体nisin的比较框架：从遗传基础到未来生物工程技术应用的联系
Negin Ghazanfari,Farideh Tabatabaei Yazdi,Seyed Ali Mortazavi et al.
Negin Ghazanfari et al.
Vibrational spectroscopy methodology for profiling of mixed carbon metabolism in carotenogenic and oleaginous Mucor circinelloides [0.03%]
用于碳环状链霉菌类胡萝卜素和产油混合代谢特征分析的振动光谱法
Simona Dzurendová,Eirik Almklov Magnussen,Volha Shapaval et al.
Simona Dzurendová et al.
Background: Mixed carbon substrate fermentation is gaining interest in industrial biotechnology for effectively utilizing sustainable resources like waste glycerol and lignocellulose to produce food, feed, biofuels, and p...
The sugar transporter STP1-driven trophic conversion of Chlamydomonas reinhardtii [0.03%]
模式绿藻小立藻转染生成糖转运蛋白STP1驱动的营养转换现象
Bum-Soo Shin,Yong Jae Lee,Jin-Ho Yun et al.
Bum-Soo Shin et al.
Towards the development of a CRISPR-Cas9 based kill switch for Saccharomyces cerevisiae [0.03%]
基于CRISPR-Cas9的酿酒酵母基因线路安全开关的构建及优化
Pavithra Umashankar,Bohyun Choi,Yvonne Nygård
Pavithra Umashankar
Engineering Pseudomonas taiwanensis VLB120 for regio- and stereospecific hydroxylation of L-lysine fueled by the Weimberg pathway [0.03%]
通过Weimberg途径供能的假单胞菌台湾株 VLB120 工程化产物立体及区域选择性L-赖氨酸羟基化反应
Philipp Nerke,Julian Handke,Georg Hubmann et al.
Philipp Nerke et al.
Background: Hydroxy-L-lysines are versatile chiral building blocks and can be obtained by hydroxylation of the amino acid L-lysine. The conversion is catalyzed by α-ketoglutarate-dependent lysine dioxygenases (KDOs), whi...
A novel stationary phase approach for improved recombinant protein expression in Escherichia coli: beyond the exponential phase [0.03%]
一种新的固定相方法可提高大肠杆菌指数生长期后的重组蛋白表达水平
Yoon-Hyeok Kang,Yong-Kyun Ryu,Jaewon Lee et al.
Yoon-Hyeok Kang et al.
Escherichia coli BL21 adapts its central carbon metabolism to recombinant protein production and oxygen limitation [0.03%]
大肠杆菌BL21适应其核心碳代谢以进行重组蛋白生产和氧气限制
Divyata Vilas Rane,Karen Lund Haaland,Åse Refsnes et al.
Divyata Vilas Rane et al.
Background: High-yielding recombinant protein expression systems often face challenges due to the metabolic burden caused by the competition for cellular resources, resulting in reduced growth and, hence, limiting their i...
Iterative enrichment cultivation and multiomic analysis reveal potential endophytic bacteria affecting the sinomenine synthesis in Sinomenium acutum [0.03%]
迭代富集培养和多组学分析揭示了影响尖叶蛇根草中哈萝因合成的内生细菌的潜力
Sili Yin,Ziyi Xiao,Zhaojing Yu et al.
Sili Yin et al.
Endophytes play important roles in plant metabolite synthesis, and certain strains were capable of producing bioactive compounds identical to those of their hosts. However, it remains unknown whether culturable endophytes of S. acutum can s...