Deletion of NTH1 and HSP12 increases the freeze-thaw resistance of baker's yeast in bread dough [0.03%]
删除NTH1和HSP12可提高面包面团中酿酒酵母的冻融耐受性
Bo-Chou Chen,Huan-Yu Lin
Bo-Chou Chen
Background: The intracellular molecule trehalose in Saccharomyces cerevisiae may have a major protective function under extreme environmental conditions. NTH1 is one gene which expresses trehalase to degrade trehalose. Sm...
Metabolic engineering of Corynebacterium glutamicum for efficient production of optically pure (2R,3R)-2,3-butanediol [0.03%]
谷氨酸棒杆菌代谢工程高效生产光学纯(2R,3R)-丁二醇
Mengyun Kou,Zhenzhen Cui,Jing Fu et al.
Mengyun Kou et al.
Background: 2,3-butanediol is an important platform compound which has a wide range of applications, involving in medicine, chemical industry, food and other fields. Especially the optically pure (2R,3R)-2,3-butanediol ca...
José Ignacio Rodríguez-Ochoa,Juan Carlos Fragoso-Jiménez,Noemí Flores et al.
José Ignacio Rodríguez-Ochoa et al.
The aromatic compound p-coumaric acid (p-CA) is a secondary metabolite produced by plants. This aromatic acid and derived compounds have positive effects on human health, so there is interest in producing them in biotechnological processes ...
Improvement of macrolactins production by the genetic adaptation of Bacillus siamensis A72 to saline stress via adaptive laboratory evolution [0.03%]
通过适应性实验室进化使芽孢杆菌SIAM S A72适应盐分压力从而提高大环内酯类物质的产量
Yuman Gan,Meng Bai,Xiao Lin et al.
Yuman Gan et al.
Background: Macrolactins, a type of macrolide antibiotic, are toxic to the producer strains. As such, its level is usually maintained below the lethal concentration during the fermentation process. To improve the producti...
Efficient production of a cyclic dipeptide (cyclo-TA) using heterologous expression system of filamentous fungus Aspergillus oryzae [0.03%]
基于丝状真菌稻曲霉异源表达体系高效生产环肽TA的研究
Jianzhao Qi,Haiyan Han,Dan Sui et al.
Jianzhao Qi et al.
Background: Cyclic dipeptides are an important class of natural products owing to their structural diversity and biological activities. In fungi, the cyclo-ring system is formed through the condensation of two α-amino ac...
Optimization of the production process for the anticancer lead compound illudin M: process development in stirred tank bioreactors [0.03%]
抗癌先导化合物illudin M生产过程的优化：搅拌罐生物反应器中的工艺开发
Lillibeth Chaverra-Muñoz,Stephan Hüttel
Lillibeth Chaverra-Muñoz
Background: The fungal natural products illudin S and M have been investigated as precursors for the development of semisynthetic anticancer agents such as Irofulven (illudin S derivative) which is currently in phase II c...
Targeting IL-6 by engineered Lactococcus lactis via surface-displayed affibody [0.03%]
通过表面展示亲和体的工程化乳酸菌靶向IL-6
Abida Zahirović,Aleš Berlec
Abida Zahirović
Background: Dysregulated production of interleukin (IL)-6 is implicated in the pathology of inflammatory bowel disease (IBD). Neutralization of IL-6 in the gut by safe probiotic bacteria may help alleviate intestinal infl...
Exploring the multi-level regulation of lignocellulases in the filamentous fungus Trichoderma guizhouense NJAU4742 from an omics perspective [0.03%]
从组学角度探讨曲霉属贵州青霉NJAU4742多水平调控木聚糖酶的机制
Yanwei Xia,Jingfan Wang,Chuanxu Guo et al.
Yanwei Xia et al.
Background: Filamentous fungi are highly efficient at deconstructing plant biomass by secreting a variety of enzymes, but the complex enzymatic regulation underlying this process is not conserved and remains unclear. ...
Efficient molasses utilization for low-molecular-weight poly-γ-glutamic acid production using a novel Bacillus subtilis stain [0.03%]
利用新型枯草芽孢杆菌高效利用糖蜜生产低分子量聚谷氨酸
Jing Li,Shengbao Chen,Jiaming Fu et al.
Jing Li et al.
Background: Poly-γ-glutamic acid (γ-PGA) is a biopolymer and has various applications based on its biocompatibility, non-toxicity, and edibility. Low-molecular-weight (Mw)-γ-PGA has promising applications in agricultur...
Efficient and scalable synthesis of 1,5-diamino-2-hydroxy-pentane from L-lysine via cascade catalysis using engineered Escherichia coli [0.03%]
一种通过工程化大肠杆菌级联催化由L-赖氨酸合成1，5-二氨基-2-羟基戊烷的方法及其应用
Yangyang Li,Alei Zhang,Shewei Hu et al.
Yangyang Li et al.
Background: 1,5-Diamino-2-hydroxy-pentane (2-OH-PDA), as a new type of aliphatic amino alcohol, has potential applications in the pharmaceutical, chemical, and materials industries. Currently, 2-OH-PDA production has only...