Immunotherapy for prostate cancer: is prostate an immune responsive tumor? [0.03%]
前列腺癌的免疫治疗：前列腺是一个免疫反应型肿瘤吗？
Susan F Slovin
Susan F Slovin
Purpose of review: The purpose of this review is to identify possible reasons why prostate cancer suboptimally responds to immune therapies. Recent findin...
Ana Collazo-Lorduy,Matthew D Galsky
Ana Collazo-Lorduy
Purpose of review: Immune checkpoint blockade results in durable responses in a subset of patients with advanced urologic tumors. However, the majority of patients do not respond to single agent therapy raising the hypoth...
Programmed cell death-1 pathway inhibitors in genitourinary malignancies: specific side-effects and their management [0.03%]
程序性细胞死亡配体-1抑制剂治疗泌尿生殖系统肿瘤的特殊不良反应及其处理措施
Abhishek Tripathi,Marina D Kaymakcalan,Nicole R LeBoeuf et al.
Abhishek Tripathi et al.
Purpose of review: Immune checkpoint inhibitors such as those that target the programmed cell death (PD)-1 pathway harness the host immune system to elicit an antitumor response. Their remarkable clinical benefit has led ...
Jean Hoffman-Censits,Lindsay Wilde
Jean Hoffman-Censits
Purpose of review: Combination immunotherapy has already shown promise in several tumor types, such as melanoma and nonsmall cell lung cancer, and studies are ongoing to evaluate this approach in other malignancies. Trial...
Max M Wattenberg,Lawrence Fong,Ravi A Madan et al.
Max M Wattenberg et al.
Purpose of review: Active investigation suggests immune checkpoint inhibitor therapy and therapeutic cancer vaccines provide clinical benefit for genitourinary malignancies including prostate cancer, renal cell carcinoma,...
Saeed Dabestani,Lorenzo Marconi,Axel Bex
Saeed Dabestani
Purpose of review: Although novel targeted therapies for metastatic renal cell carcinoma (RCC) are emerging, metastasectomy still remains the only potentially curable intervention and plays an important role both in disea...
Takashige Abe,Ryuji Matsumoto,Nobuo Shinohara
Takashige Abe
Purpose of review: Since the development of systemic combination chemotherapy, postchemotherapy extirpation has been performed in selected patients mainly with locally advanced and/or initially unresectable bladder cancer...
Joshua J Morigi,S Fanti,D Murphy et al.
Joshua J Morigi et al.
Purpose of review: PET/CT imaging in men with prostate cancer (PCa) is rapidly growing as clinicians are becoming aware of its possible fundamental role in the diagnostic flow chart of these patients. As this technology b...
Jun Gong,Benjamin Gerendash,Nazli Dizman et al.
Jun Gong et al.
Purpose of review: Multiple agents, including vascular endothelial growth factor (VEGF) inhibitors and mammalian target of rapamycin inhibitors have been approved over the past decade for the treatment of metastatic renal...
Kyle A Richards,E Jason Abel
Kyle A Richards
Purpose of reveiw: Approximately one in three patients with nonmetastatic renal cell carcinoma (RCC) at the time of surgery will subsequently develop local or metastatic recurrence. The purpose of this review is to examin...