Lara L Zimmermann,Ryan M Martin,Fady Girgis
Lara L Zimmermann
Purpose of review: Posttraumatic seizures (PTS) and posttraumatic epilepsy (PTE) are common and debilitating consequences of traumatic brain injury (TBI). Early PTS result in secondary brain injury by raising intracranial...
Jean-Francois Demonet
Jean-Francois Demonet
Iris Mildenberger,Lukas Bunse,Katharina Ochs et al.
Iris Mildenberger et al.
Purpose of review: Also owing to the limited efficacy of targeted therapies, there has been a renewed interest in targeting gliomas with immunotherapy. But despite considerable efforts using sophisticated approaches, proo...
Mehdi Touat,Daniel Talmasov,Damien Ricard et al.
Mehdi Touat et al.
Purpose of review: Immune-checkpoint inhibitors (ICIs) constitute a novel class of agents recently approved to treat a number of human malignancies. Due to their immunomodulatory mechanism of action, ICIs can generate a w...
Alicia K Au,Robert S B Clark
Alicia K Au
Purpose of review: Traumatic brain injury (TBI) is a leading cause of death and disability in children. Prognostication of outcome following TBI is challenging in this population and likely requires complex, multimodal mo...
Primary central nervous system lymphoma: time for diagnostic biomarkers and biotherapies? [0.03%]
原发中枢神经系统淋巴瘤：诊断生物标志物和生物疗法的时代来临了？
Louis Royer-Perron,Khê Hoang-Xuan,Agusti Alentorn
Louis Royer-Perron
Purpose of review: Primary central nervous system lymphoma (PCNSL) is a rare cancer with a somber prognosis in older patients, which it affects predominantly. Only in recent years have molecular alterations characterizing...
Evidence of semantic processing impairments in behavioural variant frontotemporal dementia and Parkinson's disease [0.03%]
行为变异型额颞叶痴呆和帕金森病语义处理障碍的证据
Katheryn A Q Cousins,Murray Grossman
Katheryn A Q Cousins
Purpose of review: Category-specific impairments caused by brain damage can provide important insights into how semantic concepts are organized in the brain. Recent research has demonstrated that disease to sensory and mo...
Update on tauopathies [0.03%]
tauopathy研究进展
Thibaud Lebouvier,Florence Pasquier,Luc Buée
Thibaud Lebouvier
Purpose of review: The purpose of this review is to provide an update on the role of tau beyond the stabilization of microtubules and on the clinical, pathological, diagnostic and therapeutic aspects of tauopathies. ...
Marianne de Visser,David J Oliver
Marianne de Visser
Purpose of review: Palliative care is an approach that improves the quality of life of patients and their families facing the problem associated with life-threatening illness. Neuromuscular disorders (NMDs) are characteri...
Revisiting the concept of amyotrophic lateral sclerosis as a multisystems disorder of limited phenotypic expression [0.03%]
从有限的表型表达角度重新审视肌萎缩侧索硬化这一多系统障碍的概念
Michael J Strong
Michael J Strong
Purpose of review: The current review will examine the contemporary evidence that amyotrophic lateral sclerosis (ALS) is a syndrome in which the unifying feature is a progressive loss of upper and lower motor neuron funct...