Gergo Erdi-Krausz,Pamela J Shaw
Gergo Erdi-Krausz
Purpose of review: Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder with few treatment options available. The approval of tofersen, an antisense oligonucleotide, for SOD1-ALS by the FDA and EMA ma...
Neurochemical biomarkers of amyotrophic lateral sclerosis: recent developments [0.03%]
肌萎缩侧索硬化症的神经化学生物标志物：最新进展
Federico Verde
Federico Verde
Review purpose: To provide an overview of the recent developments in the field of neurochemical biomarkers of amyotrophic lateral sclerosis (ALS). Recent ...
Christina Lang
Christina Lang
Purpose of review: This review summarizes recent evidence on sleep disturbances in amyotrophic lateral sclerosis (ALS), emphasizing their role as intrinsic features of the disease process rather than consequence of motor ...
The role of amino acid PET in the era of checkpoint inhibitors and targeted therapy for brain tumor treatment [0.03%]
免疫检查点抑制剂和靶向治疗时代脑肿瘤治疗中氨基酸PET的作用
Norbert Galldiks,Jana-Marie Peplinski,Manuel Kraft et al.
Norbert Galldiks et al.
Purpose of review: To summarize the role of diagnostic amino acid PET in the era of checkpoint inhibitors and targeted therapies for brain tumor treatment. ...
Amyotrophic lateral sclerosis in Mainland China: clinical translational challenges and opportunities [0.03%]
中国内地的肌萎缩侧索硬化症：临床转化面临的挑战和机遇
Ji He,Dongsheng Fan
Ji He
Purpose of review: Amyotrophic lateral sclerosis (ALS) imposes a growing medical and socioeconomic burden in China. This review synthesizes recent advances in understanding ALS epidemiology, biomarker discovery, therapeut...
Neuroimaging endpoints for clinical trials in gliomas: the neuro-oncologist perspective [0.03%]
胶质瘤临床试验的影像学终点：神经肿瘤学家的观点
Vihang Nakhate,Gilbert Youssef,Aleksandra B Lasica et al.
Vihang Nakhate et al.
Purpose of review: Accurate and reliable determination of tumor response and progression on neuroimaging is critical to identify effective therapies for glioma in clinical trials. In this article, we review response asses...
Grazia Devigili,Margherita Marchi,Giuseppe Lauria
Grazia Devigili
Purpose of review: Small fiber neuropathies (SFN) are a heterogeneous group of disorders affecting the thinly myelinated Aδ and unmyelinated C-fibers. The clinical picture is dominated by neuropathic pain, often accompan...
Sonja Menge,Lorena Decker,Axel Freischmidt
Sonja Menge
Purpose of review: Amyotrophic lateral sclerosis (ALS) is a complex genetic disorder, and the pace of discoveries is very rapid. This review aims at briefly summarizing our current knowledge, and at discussing the progres...
Luc Dupuis,Janice Robertson
Luc Dupuis
Purpose of review: We review here novel knock-in models of amyotrophic lateral sclerosis (ALS). Recent findings: Knock-in mouse models ...
Eveline J A Wiegers,Bart C Jacobs
Eveline J A Wiegers
Purpose of review: Guillain-Barré syndrome (GBS) is a severe but treatable form of immune-mediated neuropathy. The purpose of this review is to provide an update on current immune treatments for GBS, highlight challenges...