Headache care around the world: a review of access, equity, and system-level solutions [0.03%]
全球范围内的头痛护理：可及性、公平性和系统级解决方案综述
Aynur Özge,Amr Hassan,Marcio Nattan Portes Souza
Aynur Özge
Purpose of review: Headache disorders are the leading cause of neurological disability globally, yet their management remains marked by profound inequities in access to diagnosis, evidence-based treatment, specialist care...
Decoding Alzheimer's disease through down syndrome: insights from a genetically defined population [0.03%]
通过唐氏综合症解读阿尔茨海默病：来自遗传定义人群的启示
Jason K Russell,Zinayida Schlachetzki,Michael S Rafii
Jason K Russell
Purpose of review: This review explores Alzheimer's disease (AD) in individuals with Down syndrome (DS), a genetically defined population with near-universal development of AD neuropathology by age 40. We examine the gene...
Chronobiology and cluster headache: insights into a hypothalamic disorder [0.03%]
生物钟与丛集性头痛：下丘脑疾病的洞见
Caroline Ran,Stefan Spulber,Andrea Carmine Belin
Caroline Ran
Purpose of review: Cluster headache is a disorder which has been shown to have both a circadian and a circannual pattern. This review gives an overview of the chronobiology of cluster headache summarizing recent findings ...
Piero Perucca,Emilio Perucca
Piero Perucca
Purpose of review: To review progress in developing new pharmacological treatments for epilepsy, focusing on agents in clinical development. Recent findin...
Peripheral alterations of mitochondrial function and mitophagy in Alzheimer's disease: from fundamental research to clinical perspectives [0.03%]
阿尔茨海默病中线粒体功能及自噬在外周的改变：从基础研究到临床观点
Fanny Eysert,Gaëlle Deportes,Elodie Delaquaize et al.
Fanny Eysert et al.
Purpose of review: Alzheimer's disease (AD) is commonly defined by its hallmark brain pathologies, yet mounting evidence shows that metabolic impairment particularly linked to mitochondrial dysfunction, is a central and s...
The monoaminergic systems as drivers of Alzheimer's disease pathophysiology and symptomatology [0.03%]
单胺能系统在阿尔茨海默病病理生理和症状学中的作用
Heidi I L Jacobs
Heidi I L Jacobs
Purpose of review: To summarize recent animal, postmortem and in vivo human studies examining the role of the noradrenergic and serotonergic system in the pathophysiology and symptomatology of Alzheimer's disease (AD). ...
Eva Breuer,Bernd J Vorderwülbecke,Martin Holtkamp
Eva Breuer
Purpose of review: One in five patients with epilepsy has idiopathic generalized epilepsy (IGE). Novel definitions of seizure types, recent data on pharmacotherapy, and new studies on psychiatric and cognitive comorbiditi...
Yoav Gimmon,Carlos R Gordon
Yoav Gimmon
Purpose of review: This review highlights recent advances in neuro-vestibular rehabilitation, with emphasis on vestibular adaptation and emerging mobile technologies. It summarizes developments in promoting vestibular pla...
Sasa Vasilijic,Lindsay S Moore,Konstantina M Stankovic
Sasa Vasilijic
Purpose of review: This review provides an update on recent advances in molecular and imaging biomarker discovery for the diagnosis and prognosis of vestibular schwannoma (VS), with the goal of accelerating their validati...
Jeffrey P Staab
Jeffrey P Staab
Purpose of review: Three functional neurological disorders are encountered in neuro-otologic practice, persistent postural-perceptual dizziness (PPPD), which is the commonest cause of chronic vestibular and balance sympto...