Estée C H Feldman,Taylor Gates,Scott W Powers
Estée C H Feldman
Purpose of review: Pediatric headache not only impacts an individual's psychosocial, physical, and academic functioning, but also imposes a burden on their broader systems (e.g. healthcare, financial systems). Literature ...
Sudeshna Das,Bradley T Hyman,Alberto Serrano-Pozo
Sudeshna Das
Purpose of review: The apolipoprotein E (APOE) genotype has traditionally been associated with Alzheimer's disease (AD) and, more specifically, with the severity of cerebral β-amyloidosis in the form of Aβ plaques and c...
Headache care around the world: a review of access, equity, and system-level solutions [0.03%]
全球范围内的头痛护理：可及性、公平性和系统级解决方案综述
Aynur Özge,Amr Hassan,Marcio Nattan Portes Souza
Aynur Özge
Purpose of review: Headache disorders are the leading cause of neurological disability globally, yet their management remains marked by profound inequities in access to diagnosis, evidence-based treatment, specialist care...
Decoding Alzheimer's disease through down syndrome: insights from a genetically defined population [0.03%]
通过唐氏综合症解读阿尔茨海默病：来自遗传定义人群的启示
Jason K Russell,Zinayida Schlachetzki,Michael S Rafii
Jason K Russell
Purpose of review: This review explores Alzheimer's disease (AD) in individuals with Down syndrome (DS), a genetically defined population with near-universal development of AD neuropathology by age 40. We examine the gene...
Chronobiology and cluster headache: insights into a hypothalamic disorder [0.03%]
生物钟与丛集性头痛：下丘脑疾病的洞见
Caroline Ran,Stefan Spulber,Andrea Carmine Belin
Caroline Ran
Purpose of review: Cluster headache is a disorder which has been shown to have both a circadian and a circannual pattern. This review gives an overview of the chronobiology of cluster headache summarizing recent findings ...
Piero Perucca,Emilio Perucca
Piero Perucca
Purpose of review: To review progress in developing new pharmacological treatments for epilepsy, focusing on agents in clinical development. Recent findin...
Peripheral alterations of mitochondrial function and mitophagy in Alzheimer's disease: from fundamental research to clinical perspectives [0.03%]
阿尔茨海默病中线粒体功能及自噬在外周的改变：从基础研究到临床观点
Fanny Eysert,Gaëlle Deportes,Elodie Delaquaize et al.
Fanny Eysert et al.
Purpose of review: Alzheimer's disease (AD) is commonly defined by its hallmark brain pathologies, yet mounting evidence shows that metabolic impairment particularly linked to mitochondrial dysfunction, is a central and s...
The monoaminergic systems as drivers of Alzheimer's disease pathophysiology and symptomatology [0.03%]
单胺能系统在阿尔茨海默病病理生理和症状学中的作用
Heidi I L Jacobs
Heidi I L Jacobs
Purpose of review: To summarize recent animal, postmortem and in vivo human studies examining the role of the noradrenergic and serotonergic system in the pathophysiology and symptomatology of Alzheimer's disease (AD). ...
Eva Breuer,Bernd J Vorderwülbecke,Martin Holtkamp
Eva Breuer
Purpose of review: One in five patients with epilepsy has idiopathic generalized epilepsy (IGE). Novel definitions of seizure types, recent data on pharmacotherapy, and new studies on psychiatric and cognitive comorbiditi...
Yoav Gimmon,Carlos R Gordon
Yoav Gimmon
Purpose of review: This review highlights recent advances in neuro-vestibular rehabilitation, with emphasis on vestibular adaptation and emerging mobile technologies. It summarizes developments in promoting vestibular pla...