Asthma/obstructive pulmonary disease overlap: update on definition, biomarkers, and therapeutics [0.03%]
哮喘/阻塞性肺病重叠：定义、生物标志物和治疗的最新研究进展
August Generoso,John Oppenheimer
August Generoso
Purpose of review: Asthma/chronic obstructive pulmonary disease overlap (ACO) continues to be a poorly understood condition. This review discusses newly proposed criteria and potential biomarkers in ACO, to aid in diagnos...
Ida Mogensen,Anna James,Andrei Malinovschi
Ida Mogensen
Purpose of review: Finding suitable biomarkers to phenotype asthma, identify individuals at risk of worsening and guide treatment is highly prioritized in asthma research. We aimed to provide an analysis of currently used...
Differential expression and role of S100 proteins in chronic rhinosinusitis [0.03%]
慢性鼻窦炎中S100蛋白的差异表达及作用
Jorgen S Sumsion,Abigail Pulsipher,Jeremiah A Alt
Jorgen S Sumsion
Purpose of review: Immune system modulators have been under investigation to help elucidate the underlying pathophysiologies of chronic rhinosinusitis (CRS). Psoriasin (S100A7) and calgranulins (S100A8, S100A9, and S100A1...
Bilal Alashkar Alhamwe,Fahd Alhamdan,Andreas Ruhl et al.
Bilal Alashkar Alhamwe et al.
Purpose of review: Epigenetic mechanisms are known to play a crucial role in the pathogenesis of asthma, allergic rhinitis, atopic dermatitis, food allergy, and other allergic disorders, especially through mediating the e...
Pulmonary rehabilitation: promising nonpharmacological approach for treating asthma? [0.03%]
肺康复：治疗哮喘的有前景的非药物方法吗？
Elisabetta Zampogna,Antonio Spanevello,Dina Visca
Elisabetta Zampogna
Purpose of review: Asthma is a heterogeneous disease, usually characterized by chronic airway inflammation with a history of respiratory symptoms that vary over time and in intensity, together with variable expiratory air...
Disorders of CTLA-4 expression, how they lead to CVID and dysregulated immune responses [0.03%]
CTLA-4表达异常及其导致CVID和免疫反应失调的机制
Di Sun,Jennifer Heimall
Di Sun
Purpose of review: The landscape of common variable immunodeficiency disorder (CVID) is rapidly evolving as the availability of next-generation sequencing leads to the discovery of new monogenic causes with the clinical p...
Antonella Cianferoni,Isabella Annesi-Maesano
Antonella Cianferoni
Purpose of review: To analyze the status of precision medicine in atopic diseases. Recent findings: Atopic diseases are increasingly re...
Mark J Ponsford,Antonio Pecoraro,Stephen Jolles
Mark J Ponsford
Purpose of review: Clozapine has recently been described as a novel cause of secondary antibody deficiency (SAD), associated with long-term therapy. Here we critically review the evidence linking clozapine use to an incre...
Th2 inflammatory responses in the development of nasal polyps and chronic rhinosinusitis [0.03%]
TH2型炎症反应在鼻息肉和慢性鼻窦炎发病中的作用
Gwanghui Ryu,Dae Woo Kim
Gwanghui Ryu
Purpose of review: Pathogenesis of nasal polyp has been largely studied based on innate and adaptive immunity of sinonasal mucosa. So far, various factors have been identified that trigger an inflammatory response in the ...
Yukako Seo,Manabu Nonaka,Ruby Pawankar
Yukako Seo
Purpose of review: Eosinophilic otitis media (EOM) is an intractable otitis media characterized by numerous eosinophils infiltrating the middle ear cavity, which is part of the upper airway. EOM shows a high rate of comor...