Chromosomal rearrangement in the 22q11.2 region: a critical locus for sociability and attentional skills [0.03%]
22q11.2区域的染色体重排：一个影响社交能力与注意力技能的关键基因位点
Marie-Noëlle Babinet,Nadine Thomas,Linda Pons et al.
Marie-Noëlle Babinet et al.
Rearrangements of 22q11.2 region, most often deletions and duplications, are responsible for multiple congenital disorders. These rearrangements are involved in syndromes that share some phenotypic similarities. To date, 22q11.2 triplicatio...
Chromosomal rearrangement in the 22q11.2 region: a critical locus for sociability and attentional skills [0.03%]
22q11.2区域的染色体重排：社会性和注意力技能的关键位置
Marie-Noëlle Babinet,Nadine Thomas,Linda Pons et al.
Marie-Noëlle Babinet et al.
Rearrangements of 22q11.2 region, most often deletions and duplications, are responsible for multiple congenital disorders. These rearrangements are involved in syndromes that share some phenotypic similarities. To date, 22q11.2 triplicatio...
A novel risk variant block across introns 36-45 of CACNA1C for schizophrenia: a cohort-wise replication and cerebral region-wide validation study [0.03%]
CACNA1C第36~45内含子精神分裂症风险变异区：队列重复检验及脑区范围验证研究
Xiaoyun Guo,Shibin Wang,Xiandong Lin et al.
Xiaoyun Guo et al.
Objectives: Numerous genome-wide association studies have identified CACNA1C as one of the top risk genes for schizophrenia. As a necessary post-genome-wide association study (GWAS) follow-up, here, we focused on this ris...
A novel risk variant block across introns 36-45 of CACNA1C for schizophrenia: a cohort-wise replication and cerebral region-wide validation study [0.03%]
胶质细胞源性神经营养因子促进脑卒中后血管新生及功能恢复的机制研究中文标题：CACNA1C内含子36-45区风险变异单元与精神分裂症的相关性研究——队列验证及全脑影像学定位研究
Xiaoyun Guo,Shibin Wang,Xiandong Lin et al.
Xiaoyun Guo et al.
Objectives: Numerous genome-wide association studies have identified CACNA1C as one of the top risk genes for schizophrenia. As a necessary post-genome-wide association study (GWAS) follow-up, here, we focused on this ris...
Schizophrenia polygenic risk score and type 2 diabetes onset in older adults with no schizophrenia diagnosis [0.03%]
老年非精分诊断人群的双向障碍多基因风险评分与2型糖尿病发病之间的关系
Diana Shamsutdinova,Olesya Ajnakina,Angus Roberts et al.
Diana Shamsutdinova et al.
Objectives: An association between type 2 diabetes (T2DM) and schizophrenia has long been observed, and recent research revealed presence of shared genetic factors. However, epidemiological evidence was inconsistent, some...
'A child with Malpuech-Michels-Mingarelli-Carnevale syndrome and ADHD and major depressive disorder' [0.03%]
“1例马尔普什-米歇尔斯-明加雷利-卡内瓦莱综合征合并注意力缺陷多动障碍及重度抑郁障碍患儿”
Berna Aygün,Nur Seda Gülcü Üstün
Berna Aygün
Malpuech-Michels-Mingarelli-Carnevale (3MC) syndrome, is a rare genetic condition resulting from the combination of four autosomal recessive syndromes which were classified as separate syndromes earlier. 3MC syndrome may be accompanied by a...
Yehong Lu,Ruijie Zhang,Qiang Zheng
Yehong Lu
Background: The association between depression and sarcopenia has been reported in observational studies but the causality of depression on sarcopenia remained unknown. We aimed to assess the causal effect between major d...
Srishti Vashishtha,Stefan Kloiber,Gwyneth Zai
Srishti Vashishtha
Treatment of anxiety disorders primarily includes pharmacological treatment and psychotherapy, yet a substantial portion of patients do not experience sufficient clinical response. Given the significant impact of anxiety disorders on well-b...
Integrated multi-omics analysis identifies epigenetic alteration related to neurodegeneration development in post-traumatic stress disorder patients [0.03%]
整合多组学分析识别与创伤后应激障碍患者神经退行性病变相关的表观遗传改变
Ayeh Bolouki,Moosa Rahimi,Negar Azarpira et al.
Ayeh Bolouki et al.
Introduction: Post-traumatic stress disorder (PTSD), is associated with an elevated risk of neurodegenerative disorders, but the molecular mechanism was not wholly identified. Aberrant methylation status and miRNA express...
White matter volume and myelin oligodendrocyte glycoprotein (MOG) microsatellites in pediatric obsessive-compulsive disorder [0.03%]
儿童强迫症的白质体积和少突胶质细胞髓鞘糖蛋白(MOG)微卫星
Gwyneth Zai,Clement C Zai,Paul D Arnold et al.
Gwyneth Zai et al.
The myelin oligodendrocyte glycoprotein ( MOG ) gene plays an important role in myelination and has been implicated in the genetics of white matter changes in obsessive-compulsive disorder (OCD). We examined the association between variatio...