Comparison of microRNA expression levels in patients with schizophrenia before and after electroconvulsive therapy [0.03%]
电休克治疗精神分裂症患者前后微小核糖核酸表达水平比较
Nazife Gamze Usta Saglam,Mehmet Bugrahan Duz,Seda Salman Yilmaz et al.
Nazife Gamze Usta Saglam et al.
Objective: Exploring the role of microRNAs in the antipsychotic efficacy of electroconvulsive therapy (ECT) will contribute to understanding the underlying mechanism through which ECT exerts its therapeutic effects. The p...
Comparative Study
Psychiatric genetics. 2024 Aug 1;34(4):79-85. DOI:10.1097/YPG.0000000000000371 2024
Whole-exome-based single nucleotide variants and copy number analysis for prenatal diagnosis of compound heterozygosity of SMPD4 [0.03%]
基于全外显子的单核苷酸变异和拷贝数分析用于SMPD4复合杂合突变产前诊断
Jun Du,Lin Li,Dinghu Fu
Jun Du
Background: Biallelic loss-of-function variants in SMPD4 cause a rare and severe neurodevelopmental disorder. These variants have been identified in a group of children with neurodevelopmental disorders with microcephaly,...
Could the 14q23.2 microdeletion or AKAP5 haploinsufficiency be a potential cause of intellectual disability? [0.03%]
14q23.2微缺失或AKAP5单倍剂量不足可能是智力障碍的潜在致病因素吗？
Fayize Maden Bedel,Özgür Balasar,Ayşe Şimşek et al.
Fayize Maden Bedel et al.
Intellectual disability is characterized by impairment in at least two of the following areas: social skills, communication skills, self-care tasks, and academic skills. These impairments are evaluated in relation to the expected standards ...
The ethics of polygenic scores in psychiatry: minefield or opportunity for patient-centered psychiatry? [0.03%]
精神科多基因评分的伦理问题：地雷阵还是以患者为中心的精神病学的机会？
Roel H P Wouters,Marte Z van der Horst,Cora M Aalfs et al.
Roel H P Wouters et al.
Recent advancements in psychiatric genetics have sparked a lively debate on the opportunities and pitfalls of incorporating polygenic scores into clinical practice. Yet, several ethical concerns have been raised, casting doubt on whether fu...
A pathogenic P4HTM gene variant in two brothers with autism spectrum disorder [0.03%]
两名患有自闭症谱系障碍的兄弟携带致病的P4HTM基因变异
Nur Seda Gülcü Üstün
Nur Seda Gülcü Üstün
Autism spectrum disorder is a neurodevelopmental condition that involves limitations in social communication and various stereotypical repetitive behaviors. Genetic and environmental factors both play a role in the etiology. Numerous geneti...
Mechanism of electroconvulsive therapy in schizophrenia: a bioinformatics analysis study of RNA-seq data [0.03%]
电休克疗法在精神分裂症中作用机制的研究：一项RNA序列数据的生物信息学分析研究
Tingting Wang,Minglan Yu,Xiaochu Gu et al.
Tingting Wang et al.
Objective: The molecular mechanism of electroconvulsive therapy (ECT) for schizophrenia remains unclear. The aim of this study was to uncover the underlying biological mechanisms of ECT in the treatment of schizophrenia u...
Diagnostic significance and potential function of miR-320d in schizophrenia [0.03%]
mir-320d在精神分裂症中诊断意义及其潜在功能研究
Fangfang Ren,Qi Si,Yuxiu Sui
Fangfang Ren
Objectives: Schizophrenia is a chronic brain disorder and needs objective diagnostic biomarkers. MicroRNAs are highly expressed in the nervous system. The study investigated the expression and clinical values of serum miR...
Causal link between gut microbiome and schizophrenia: a Mendelian randomization study [0.03%]
肠道微生物群和精神分裂症之间的因果关系：一项孟德尔随机化研究
Qi Zeng,Min Zhang,Renxi Wang
Qi Zeng
Objective: Some observational studies have shown that gut microbiome is significantly changed in patients with schizophrenia. We aim to identify the genetic causal link between gut microbiome and schizophrenia. ...
Causal association of attention-deficit/hyperactivity disorder and autism spectrum disorder with post-traumatic stress disorder [0.03%]
注意缺陷多动障碍和自闭谱系障碍与创伤后应激障碍的因果关联性研究
Yuqing Song,Yi Zhao,Ancha Baranova et al.
Yuqing Song et al.
Background: Attention-deficit/hyperactivity disorder (ADHD) and autism spectrum disorder (ASD) are two neurodevelopmental disorders that often result in individuals experiencing traumatic events. However, little is known ...