Dissecting the genetic interaction between breast cancer risk and schizophrenia: evidence from crosstrait genome-wide analysis [0.03%]
通过跨性状全基因组分析探讨乳腺癌易感性和精神分裂症之间的遗传互作关系
Min Zhang,Yongli Wu,Yujie Qin
Min Zhang
Background: Epidemiological evidence suggests a link between schizophrenia (SCZ) and increased breast cancer (BC) risk, but the genetic mechanisms remain unclear. Exploring their shared genetic susceptibility may help rev...
Functional evaluation of NAA10 variants in patients with Ogden syndrome [0.03%]
Ogden综合征患者中NAA10变异的功能评估
Aydeniz Aydin Gumus,Mustafa Dogan,Alper Gezdirici et al.
Aydeniz Aydin Gumus et al.
Objectives: The catalytic subunit of NatA, the main component of the N-terminal acetyltransferase complex, which is involved in most of the acetylation of the human proteome, is encoded by the NAA10 gene. Mutations in the...
Shared genetic architecture between autism spectrum disorder, loneliness, and social isolation reveals novel genetic loci [0.03%]
自闭症光谱障碍、孤独感和社交孤立之间共享的基因结构揭示了新的基因位置
Sigrun Hope,Aihua Lin,Linn Rodevand et al.
Sigrun Hope et al.
Objective: Deficits in social communication and social interaction are core features of autism spectrum disorder (ASD), and studies suggest that loneliness and social isolation are common. ASD has a strong genetic basis, ...
Relationship between symptom severity, glutamate levels, and N-methyl-D-aspartate receptor target microRNA expression in patients with panic disorder [0.03%]
症状严重程度、谷氨酸水平与谷氨酸受体靶向微小核糖核酸在惊恐障碍患者中的相关性研究
Tuba Tuğ Altunöz,Nazan Dolapoğlu,Özgür Baykan et al.
Tuba Tuğ Altunöz et al.
Background: Glutamate, an excitatory neurotransmitter in the central nervous system, plays a role in neurodevelopment, learning, and memory. It is thought to interact with the GABAergic system in the development of panic ...
Bidirectional genetic overlap between mood swings and irritable bowel syndrome [0.03%]
心境波动和易激惹性肠综合征的双向遗传重叠
Qinghua Luo,Jiawen Wang,Mingwei An et al.
Qinghua Luo et al.
Background: Mood swings and irritable bowel syndrome (IBS) are closely related. However, the reason for the clinical concurrence of this phenomenon is unknown, and maybe it is because the two share genetic underpinnings. ...
Bidirectional genetic overlap between mood swings and irritable bowel syndrome [0.03%]
心境波动与易激惹性肠综合征的双向遗传重叠现象
Qinghua Luo,Jiawen Wang,Mingwei An et al.
Qinghua Luo et al.
Background: Mood swings and irritable bowel syndrome (IBS) are closely related. However, the reason for the clinical concurrence of this phenomenon is unknown, and maybe it is because the two share genetic underpinnings. ...
Yanzhao Chen,Yaming Xia,Lipeng Chen et al.
Yanzhao Chen et al.
Objective: Developmental and epileptic encephalopathy 9 (DEE9) is an X-linked genetic disorder characterized by the onset of seizures during infancy. Mutations in protocadherin 19 (PCDH19) are the main cause of DEE9. Our ...
Polygenic risks and cardiovascular treatment effects in severe mental illness [0.03%]
精神疾病中的多基因风险和心血管治疗效果
Kai Yao,Alexandra Burton,Samira Heinkel et al.
Kai Yao et al.
Objective: Patients with severe mental illness (SMI) experience increased cardiovascular risks, leading to reduced life expectancy. Polygenic risk scores (PRS) prediction is promising for assessing cardiovascular risks. T...
Neonatal genetic screening in Changsha: a multicenter study and preliminary findings [0.03%]
长沙新生儿遗传病筛查多中心研究及初步结果分析
Jun He,Jingjing Zhang,Shuanglin Xiang et al.
Jun He et al.
Background: Newborn screening (NBS) is a public health service aimed at identifying infants with severe genetic disorders. Genetic testing is now commonly used for secondary or confirmatory testing after a positive result...
Downregulation of NOTCH1 and NOTCH4 signalling influences the modulation of schizophrenia onset [0.03%]
NOTCH1和NOTCH4信号通路的下调对精神分裂症发病的影响作用研究
Uddip Talukdar,Abhijit Bharali,Swapna D Kakoty et al.
Uddip Talukdar et al.
Background: Schizophrenia is a chronic neuropsychiatric disorder characterised by a range of positive and negative symptoms. The genetic aspect of schizophrenia is highly pleiotropic, as the complete set of neurodevelopme...