Is the significant superiority of escitalopram compared with other antidepressants clinically relevant? [0.03%]
艾司西酞普兰相比其他抗抑郁药的显著优势有临床意义吗？
Stuart A Montgomery,Hans-Jürgen Möller
Stuart A Montgomery
The methods of assessing the clinical relevance of a significant difference between antidepressants and placebo are discussed. The commonly used criteria of treatment effect and responder rates, as well as the percentage difference in respo...
Michael A Green,Mark N Abraham,Adam J Horn et al.
Michael A Green et al.
Aseptic meningitis could be a rare side effect of lamotrigine. Aseptic meningitis is a clinical condition where symptoms, signs and laboratory findings are consistent with meningeal inflammation but routine bacterial cultures are negative. ...
Impact of gastrointestinal symptoms on response to pregabalin in generalized anxiety disorder: results of a six-study combined analysis [0.03%]
一项六项研究联合分析的结果：胃肠道症状对广泛性焦虑障碍患者普瑞巴林反应的影响
Dan J Stein,R Bruce Lydiard,Barry K Herman et al.
Dan J Stein et al.
The objective of the study was to evaluate the response of generalized anxiety disorder (GAD) patients with prominent gastrointestinal (GI) symptoms to pregabalin (PGB) treatment. Data were pooled from six double-blind, placebo (PBO)-contro...
Remission, response without remission, and nonresponse in major depressive disorder: impact on functioning [0.03%]
抑郁症的缓解、未缓解的反应和无反应对功能的影响
Madhukar H Trivedi,Patricia K Corey-Lisle,Zhenchao Guo et al.
Madhukar H Trivedi et al.
Major depressive disorder (MDD) is associated with significant functional impairment. This post-hoc analysis of data from two randomized trials assessed the impact of response status on functioning in MDD. Patients with at least one histori...
Placebo-controlled inpatient comparison of venlafaxine and fluoxetine for the treatment of major depression with melancholic features [0.03%]
用于治疗抑郁发作且伴有忧郁特征的氟西汀和文拉法辛住院患者对照研究
David V Sheehan,Charles B Nemeroff,Michael E Thase et al.
David V Sheehan et al.
The objective of this study was to compare venlafaxine and fluoxetine with placebo in treating major depressive disorder with melancholic features. Adult inpatients with Diagnostic and Statistical Manual of Mental Disorders, fourth edition ...
Randomized Controlled Trial
International clinical psychopharmacology. 2009 Mar;24(2):61-86. DOI:10.1097/YIC.0b013e32831980f2 2009
Determination of pharmacokinetic properties of clozapine and norclozapine in Korean schizophrenia patients [0.03%]
测定韩国精神分裂症患者氯氮平及N-去甲基氯氮平的药代动力学性质
Seung-Tae Lee,Seunghyong Ryu,Hee Jung Nam et al.
Seung-Tae Lee et al.
There is a wide interethnic variance in the pharmacokinetic profile of clozapine (CLZ), but the accumulated data are limited to some regional populations. In this study, we investigated the pharmacokinetic profile of CLZ in Korean patients ...
Feasibility of a slower lamotrigine titration schedule for bipolar depression: a naturalistic study [0.03%]
拉莫三嗪缓慢滴定治疗方案用于双相抑郁的可行性：一项自然观察研究
Soo Hyun Joe,Jae Seung Chang,Seunghee Won et al.
Soo Hyun Joe et al.
The development of a skin rash is often associated with a rapid escalation of lamotrigine dose. We used lamotrigine to treat 259 patients with Diagnostic and Statistical Manual of Mental Disorders, 4th edition, bipolar depression using eith...
Immediate-release vs. prolonged-release lithium formulations in bipolar disorder: a 2-year comparative study [0.03%]
双相情感障碍中 Immediate-release 和 prolonged-release 锂剂配方的对比研究：一项为期两年的研究
The aim of this study is to evaluate the therapeutic outcomes, tolerability, and adherence to immediate-release (IR) and prolonged-release (PR) lithium formulations in patients with bipolar disorder (BD) over a 2-year follow-up. This natura...