Drug development in autism spectrum disorder: genetic heterogeneity, failed trials, and the case for stratified pharmacotherapy [0.03%]
孤独症药物研发：遗传异质性、临床试验失败和分层治疗的案例分析
Riccardo Bortoletto,Giuseppe Fanelli,Marco Colizzi
Riccardo Bortoletto
Despite three decades of clinical trials, no pharmacological treatment has shown consistent efficacy for the core features of autism spectrum disorder (ASD), and regulatory approvals remain limited to risperidone and aripiprazole for severe...
Aripiprazole‑induced akathisia associated with bilateral putaminal hypermetabolism on PET [0.03%]
阿立哌唑致不安症伴双侧苍白球代谢增高PET表现一则
Nicola Meda,Marialaura Lussignoli,Alessio A Gugliotta et al.
Nicola Meda et al.
Akathisia is a common and often disabling adverse effect of antipsychotic treatment. Although previous studies have linked akathisia to dopamine D2‑receptor blockade in the basal ganglia, there is limited evidence from [18F]fluorodeoxygluc...
Defining treatment-resistant depression in a real-world setting: impact of a staging model on clinical features and treatment trajectories [0.03%]
在真实世界环境下定义难治性抑郁病：发展阶段模型对临床症状和治疗过程的影响
Matteo Carminati,Mattia Tondello,Chiara Morana et al.
Matteo Carminati et al.
Operationalizing treatment-resistant depression (TRD) is essential to guide the rational use of pharmacological and somatic interventions. This study applied a staged TRD model in a real-world inpatient setting to disentangle patterns assoc...
Long-acting injectable vs. oral antipsychotics during electroconvulsive therapy in psychosis: a retrospective comparative study [0.03%]
长效抗精神病注射药物与口服药物在精神疾病电休克治疗期间的比较研究
Hee Won Jeong,Yong Sik Kim,Eui-Joong Kim et al.
Hee Won Jeong et al.
Psychoses are often characterized by relapse and treatment resistance. Patients receiving electroconvulsive therapy (ECT) represent a high-risk subgroup. Although long-acting injectable (LAI) antipsychotics improve adherence compared with o...
Association between the number of delirium-associated medications and postoperative delirium in older adults: a multicenter retrospective study [0.03%]
药物相关性谵妄与老年患者术后谵妄的关联：多中心回顾性研究
Masakazu Hatano,Rintaro Sogawa,Haruna Araki et al.
Masakazu Hatano et al.
A variety of medications contribute to the risk of postoperative delirium (POD) in older adults. This multicenter retrospective study aimed to investigate the relationship between the number of delirium-associated medication types and the i...
Preliminary evidence that blood extracellular nicotinamide phosphoribosyltransferase increases with antidepressant response to chronotherapeutics and to monoaminergic drugs [0.03%]
初步证据表明，血液中的细胞外烟酰胺单磷酸核糖转移酶随着针对情绪障碍的联合疗法以及单胺类药物治疗的抗抑郁作用增强而增加
Francesco Benedetti,Igor Branchi,Ha Kyung Shin et al.
Francesco Benedetti et al.
The purpose of the present study is to provide a preliminary evidence of the possible involvement of extracellular nicotinamide phosphoribosyltransferase (eNAMPT) in antidepressant response. NAMPT is the major regulator of the cellular avai...
From cognitive endpoints to clinical reality in schizophrenia: antipsychotic choice, adherence, and functional outcomes [0.03%]
从认知终点到临床现实：抗精神病药物的选择、依从性和功能结局
Alessandro Serretti
Alessandro Serretti
Risperidone- and paliperidone-induced hyperprolactinemia in routine clinical practice: demographic and pharmacological determinants from the UAE [0.03%]
利培酮和帕利哌酮在临床实践中的高泌乳素血症诱导作用：来自阿联酋的药代动力学指标
Dina Aly El-Gabry,Hind Mohd Ahmed,Gabriel Andrade et al.
Dina Aly El-Gabry et al.
Antipsychotic-induced hyperprolactinemia is a common and clinically relevant adverse effect of dopamine D2-blocking agents such as risperidone and paliperidone, yet evidence from Arab populations is scarce. This study explored demographic a...
Samidorphan sadness: does the addition of samidorphan to olanzapine have prodepressive effects? [0.03%]
萨米多弗兰的忧郁：利斯卡林联合奥氮平是否有促抑郁作用？
Jamie A Parkerson,Angelo I Chaia,Sean T Lynch et al.
Jamie A Parkerson et al.
Olanzapine-samidorphan (Lybalvi) combines the antipsychotic olanzapine with the opioid receptor modulator samidorphan to mitigate olanzapine-associated weight gain. While clinical trials have supported comparable efficacy and improved metab...
Antipsychotic polypharmacy in Japanese outpatients with schizophrenia: prevalence and sex- and age-related patterns [0.03%]
日本 schizophrenic 病人抗精神病药物联合使用现象：发生率和性别及年龄相关模式
Rintaro Sogawa,Junji Uno,Akira Yoshimi et al.
Rintaro Sogawa et al.
Antipsychotic polypharmacy (APP), defined as the concurrent use of two or more antipsychotic agents, remains common in clinical practice despite antipsychotic monotherapy being the recommended standard for schizophrenia treatment. This nati...