Expanding the horizon of brexpiprazole augmentation in treatment-resistant disorders: from obsessive-compulsive disorder to adolescent bipolar disorder [0.03%]
扩增难治性疾病的用药选择范围：从强迫症到青少年双相情感障碍使用布瑞哌唑辅助治疗的研究展望
Yiğit Özaydin,Fevzi Tuna Ocakoğlu,Eyüp Sabri Ercan
Yiğit Özaydin
Acceptability-adjusted speed in psychotic agitation: interpreting pro re nata antipsychotic data in real-world care (commentary on Hatta et al.) [0.03%]
关于躁动症的可接受调整速度：对Hatta等人的现实时护理抗精神病药物数据的解读（评论）
Vassilis Martiadis
Vassilis Martiadis
Antipsychotics in clinical practice: agitation, polypharmacy, and treatment resistance [0.03%]
临床实践中的抗精神病药物：激越、多重用药和治疗抵抗性
Alessandro Serretti
Alessandro Serretti
Methylphenidate treatment in adults with comorbid attention-deficit/hyperactivity disorder and borderline personality disorder: a prospective longitudinal study [0.03%]
注意缺陷多动障碍与边缘型人格障碍成人患者的哌甲酯治疗：一项前瞻性纵向研究
Giulio Emilio Brancati,Martina Marcenaro,Elena Costagli et al.
Giulio Emilio Brancati et al.
Attention-deficit/hyperactivity disorder (ADHD) and borderline personality disorder (BPD) frequently co-occur. However, evidence on the clinical effects of stimulant treatment in ADHD-BPD comorbidity remains limited. This prospective study ...
Association between anxious depression and clinical outcomes in subjects with treatment-resistant depression: a comparative effectiveness research trial for antidepressant incomplete and non-responders with treatment-resistant depression (ASCERTAIN-TRD) [0.03%]
难治性抑郁症患者焦虑型抑郁与临床预后的关系：抗抑郁药部分反应者和无反应者的难治性抑郁症比较效果研究（ASCERTAIN-TRD）
Stefania Chaikali,Clotilde Guidetti,Silvia Ioannou et al.
Stefania Chaikali et al.
Objective: Anxious depression is a negative prognostic factor linked to worse outcomes in major depressive disorder (MDD). However, its role in treatment-resistant depression (TRD) remains unclear. This secondary analysis...
Drug development in autism spectrum disorder: genetic heterogeneity, failed trials, and the case for stratified pharmacotherapy [0.03%]
孤独症药物研发：遗传异质性、临床试验失败和分层治疗的案例分析
Riccardo Bortoletto,Giuseppe Fanelli,Marco Colizzi
Riccardo Bortoletto
Despite three decades of clinical trials, no pharmacological treatment has shown consistent efficacy for the core features of autism spectrum disorder (ASD), and regulatory approvals remain limited to risperidone and aripiprazole for severe...
Aripiprazole‑induced akathisia associated with bilateral putaminal hypermetabolism on PET [0.03%]
阿立哌唑致不安症伴双侧苍白球代谢增高PET表现一则
Nicola Meda,Marialaura Lussignoli,Alessio A Gugliotta et al.
Nicola Meda et al.
Akathisia is a common and often disabling adverse effect of antipsychotic treatment. Although previous studies have linked akathisia to dopamine D2‑receptor blockade in the basal ganglia, there is limited evidence from [18F]fluorodeoxygluc...
Defining treatment-resistant depression in a real-world setting: impact of a staging model on clinical features and treatment trajectories [0.03%]
在真实世界环境下定义难治性抑郁病：发展阶段模型对临床症状和治疗过程的影响
Matteo Carminati,Mattia Tondello,Chiara Morana et al.
Matteo Carminati et al.
Operationalizing treatment-resistant depression (TRD) is essential to guide the rational use of pharmacological and somatic interventions. This study applied a staged TRD model in a real-world inpatient setting to disentangle patterns assoc...
Long-acting injectable vs. oral antipsychotics during electroconvulsive therapy in psychosis: a retrospective comparative study [0.03%]
长效抗精神病注射药物与口服药物在精神疾病电休克治疗期间的比较研究
Hee Won Jeong,Yong Sik Kim,Eui-Joong Kim et al.
Hee Won Jeong et al.
Psychoses are often characterized by relapse and treatment resistance. Patients receiving electroconvulsive therapy (ECT) represent a high-risk subgroup. Although long-acting injectable (LAI) antipsychotics improve adherence compared with o...
Association between the number of delirium-associated medications and postoperative delirium in older adults: a multicenter retrospective study [0.03%]
药物相关性谵妄与老年患者术后谵妄的关联：多中心回顾性研究
Masakazu Hatano,Rintaro Sogawa,Haruna Araki et al.
Masakazu Hatano et al.
A variety of medications contribute to the risk of postoperative delirium (POD) in older adults. This multicenter retrospective study aimed to investigate the relationship between the number of delirium-associated medication types and the i...