Abraham Joseph Pellissery,Poonam Gopika Vinayamohan,Kumar Venkitanarayanan
Abraham Joseph Pellissery
Introduction. Clostridioides difficile is an enteric pathogen that causes a serious toxin-mediated colitis in humans. Bacterial exotoxins and sporulation are critical virulence components that contribute to pathogenesis, and disease transmi...
The bacterial neurometabolic signature of the gut microbiota of young children with autism spectrum disorders [0.03%]
幼儿自闭症患者肠道微生物的神经代谢标志
Olga V Averina,Alexey S Kovtun,Svetlana I Polyakova et al.
Olga V Averina et al.
Introduction. The human gut microbiota is currently seen as an important factor that can promote autism spectrum disorder (ASD) development in children.Aim. This study aimed to detect differences in the taxonomic composition and content of ...
Cronobacter sakazakii induces necrotizing enterocolitis by regulating NLRP3 inflammasome expression via TLR4 [0.03%]
阪崎肠杆菌通过TLR4调节NLRP3炎性小体的表达诱导坏死性小肠结肠炎
Zhenhui Chen,Yiduo Zhang,Ruqin Lin et al.
Zhenhui Chen et al.
Introduction. Neonatal infection with Cronobacter sakazakii can cause severe intestinal damage and necrotizing enterocolitis (NEC). The inflammasome and Toll-like receptors mediate intestinal damage caused by other intestinal pathogens caus...
A pooled analysis of patients with wound infections in the Phase 3 REVIVE trials: randomized, double-blind studies to evaluate the safety and efficacy of iclaprim versus vancomycin for treatment of acute bacterial skin and skin structure infections [0.03%]
III期REVIVE试验中受试者伤口感染的汇总分析：随机双盲研究评估Iclaprim治疗急性细菌性皮肤和皮肤结构感染的疗效和安全性
Stephanie Noviello,G Ralph Corey,Thomas L Holland et al.
Stephanie Noviello et al.
Introduction. Iclaprim is a diaminopyrimidine antibiotic for the treatment of acute bacterial skin and skin structure infections (ABSSSI) due to Gram-positive pathogens.Aim. This analysis evaluates patients with wound infections from two Ph...
Antimicrobial resistance prevalence in commensal Escherichia coli from broilers, fattening turkeys, fattening pigs and veal calves in European countries and association with antimicrobial usage at country level [0.03%]
欧洲家养肉鸡、育肥火鸡、育肥猪和小牛肉牛中条件致病性大肠杆菌的耐药率及与国家水平抗菌药物使用量之间的关系
Daniela Ceccarelli,Ayla Hesp,Jeanet van der Goot et al.
Daniela Ceccarelli et al.
The aim of this article is to report on antimicrobial resistance (AMR) in commensal Escherichia coli from livestock from several European countries. The relationships with antimicrobial usage (AMU) at country level and harmonized indicators...
Hydroxyethoxy phenyl butanone, a new cosmetic preservative, does not cause bacterial cross-resistance to antimicrobials [0.03%]
羟乙氧基苯丁酮是一种新型的化妆品防腐剂，并不会导致细菌对杀菌剂产生交叉耐药性
Rebecca Wesgate,Florence Menard-Szczebara,Ahmad Khodr et al.
Rebecca Wesgate et al.
Introduction. Biocide-induced cross-resistance to antimicrobials in bacteria has been described and is a concern for regulators. We have recently reported on a new protocol to predict the propensity of biocide to induce phenotypic resistanc...
Repurposing bioactive compounds for treating multidrug-resistant pathogens [0.03%]
再利用生物活性化合物治疗多重耐药病原体
Nicholas A Hummell,Natalia V Kirienko
Nicholas A Hummell
Introduction. Antimicrobial development is being outpaced by the rising rate of antimicrobial resistance in the developing and industrialized world. Drug repurposing, where novel antibacterial functions can be found for known molecular enti...
Phenotypic and molecular characterization of macrolide resistance mechanisms among Streptococcus pneumoniae isolated in Tunisia [0.03%]
在突尼斯分离的肺炎链球菌中大环内酯类耐药机制的表型和分子特征分析
B Midouni Ayadi,E Mehiri,H Draoui et al.
B Midouni Ayadi et al.
Introduction. Streptococcus pneumoniae is responsible for many community infections, with the main ones being pneumonia and meningitis. Pneumococcus has developed increased resistance to multiple classes of antibiotics. The evolution of ant...
Rapid molecular testing for Staphylococcus aureus bacteraemia improves clinical management [0.03%]
针对金黄色葡萄球菌败血症的快速分子检测改善了临床治疗
Martin P McHugh,Benjamin J Parcell,Fiona M MacKenzie et al.
Martin P McHugh et al.
Introduction. Staphylococcus aureus bacteraemia (SAB) causes significant morbidity and mortality. Standard diagnostic methods require 24-48 h to provide results, during which time management is guideline-based and may be suboptimal.Aim. Eva...
Delivery of antibacterial silver nanoclusters to Pseudomonas aeruginosa using species-specific DNA aptamers [0.03%]
利用物种特异性DNA适配体向铜绿假单胞菌传递抗菌银纳米团簇
Jennifer Soundy,Darren Day
Jennifer Soundy
Introduction. The use of silver as an antimicrobial therapeutic is limited by its toxicity to host cells compared with that required to kill bacterial pathogens.Aim. To use aptamer targeting of DNA scaffolded silver nanoclusters as an antim...