Molecular epidemiology of rodent-borne Leptospira spp. in Sri Lanka: identification of novel sequence types and previously unrecognized reservoir animals [0.03%]
斯里兰卡 rodents传播的钩端螺旋体分子流行病学：新序列型别和之前未被认识到的宿主动物的识别
Nipun Rathnayake,Kyosuke Takabe,Devinda Muthusinghe et al.
Nipun Rathnayake et al.
Introduction. Leptospirosis is an important zoonotic disease globally, which is most prevalent in tropical regions. This disease is endemic in Sri Lanka, where the complex ecology of Leptospira spp., reservoir animals and environmental and ...
Trimethoprim: bactericidal or bacteriostatic activity is dependent on bacterial growth conditions [0.03%]
甲氧芐氨嘧啶的杀菌或抑菌作用取决于细菌的生长条件
Cailean Carter,John Wain,Gemma C Langridge
Cailean Carter
Trimethoprim is a clinically important antibiotic used for the routine treatment of urinary tract infections as a cost-effective first-line choice for treatment. A unique feature of the drug is that it can have bacteriostatic or bactericida...
Can commensals alter pathogen's antibiotic resistance during co-culture? [0.03%]
共生生物能在共培养过程中改变病原体的抗生素抗性吗？
Alexander D H Kingdon,Elena Jordana-Lluch,Kim Rachael Hardie
Alexander D H Kingdon
Introduction. Bacterial infections of skin wounds can increase hospitalization duration and lead to worse patient prognoses, especially for burn wounds and diabetic foot ulcers. The two main pathogens which infect these wounds are Pseudomon...
Cryptococcus neoformans responds to presence of Mycobacterium by diversifying its morphologies and remodelling its capsular material [0.03%]
新生隐球菌通过改变形态和重塑荚膜物质来响应结核分支杆菌的存在
Orlando Ross,Andrew Akampurira,Liliane Mukaremera et al.
Orlando Ross et al.
Introduction . Cryptococcus neoformans and Mycobacterium tuberculosis (MTb) are opportunistic pathogens that share overlapping geographical distributions and physiological niches within the human body. Both are recognized by the World Healt...
Xiao Xuan Huang,Nadezda Urosevic,Timothy J J Inglis
Xiao Xuan Huang
Introduction. Recently, flow cytometry has gained the attention of clinical microbiologists for its ability to characterize bacterial species. This article shows how acoustic-enhanced flow cytometry, combined with the fluorescent dye SYTO 9...
Galleria mellonella as a versatile model for investigating Candida glabrata virulence and antifungal resistance [0.03%]
卡帕氏仓鼠熔枝芽孢杆菌作为研究光滑假丝酵母菌毒力和抗真菌耐药性的多功能模型系统
Charlie J D Holt,Catrin C Wiliams,Jane Usher
Charlie J D Holt
Candida glabrata is an opportunistic fungal pathogen and a leading cause of invasive candidiasis, particularly in immunocompromised patients, where treatment is increasingly compromised by intrinsic and acquired antifungal resistance. Despi...
Streamlining Borrelia burgdorferi cultivation using quantitative PCR screening [0.03%]
采用定量PCR筛选简化伯氏疏螺旋体培养流程
Beat M Greiter,Semjon Sidorov,Ester Osuna et al.
Beat M Greiter et al.
Introduction. Direct detection of Borrelia burgdorferi by culture is considered the gold standard for confirming Lyme disease (LD). However, B. burgdorferi culture is not routinely used in clinical practice or research due to its lengthy pr...
Public health surveillance of Vibrio cholerae in travellers returning to the United Kingdom [0.03%]
往返英国旅客中的霍乱弧菌公共卫生监测
Ching-Ying J Poh,David R Greig,Ella V Rodwell et al.
Ching-Ying J Poh et al.
Introduction. Vibrio cholerae is a diverse species of bacteria that causes watery diarrhoea, vomiting and stomach cramps and is the aetiological agent of cholera.Gap statement. Despite the global upsurge in notifications of cholera and conc...
Regulation of virulence factors of Pseudomonas aeruginosa by Scutellaria baicalensis, Prunella vulgaris and antimicrobial peptide LL-37 [0.03%]
黄芩和鼠尾草等对铜绿假单胞菌毒力因子的调节作用
Qian Xiao,Kaiwen Du,Li Luo et al.
Qian Xiao et al.
Introduction. The increasing resistance and the pathogen's complex multi-drug resistance mechanisms made the selection of effective antimicrobial treatments more challenging for Pseudomonas aeruginosa (P. aeruginosa). The study aimed to exp...
SCFAs' pleiotropic role in pathogenesis and salutogenesis: mechanisms in exacerbation and regulation of inflammation and fibrosis from gut to host [0.03%]
短链脂肪酸在致病和生健康中的多效性作用：从肠道到宿主炎症和纤维化加剧与调控的机制
Saleem Ahmad,Sikander Ali,Asad Ur Rehman et al.
Saleem Ahmad et al.
Short-chain fatty acids (SCFAs) are essential gut microbiota metabolites with significant effects that are well recognized for their anti-inflammatory benefits, yet their pro-inflammatory and pleiotropic properties have received little atte...