Clinician perspectives on patient consent for metagenomic next-generation sequencing of blood samples for the diagnosis of infection in clinical practice [0.03%]
临床医生对血液样本的宏基因组下一代测序诊断感染患者知情同意的意见
Tom G S Williams,Helen Umpleby,Temitope Fisayo et al.
Tom G S Williams et al.
Introduction. Pathogen diagnostics based on metagenomic next-generation sequencing (mNGS) are now in clinical use. mNGS can identify unexpected pathogens or organisms of unclear significance and generate human genomic data. Given these feat...
Pulmonary cryptococcosis in routine care: the clinical-radiologic spectrum and transparent evidence-tier reporting (confirmed versus presumed) among patients with no recorded immunocompromising conditions [0.03%]
非免疫缺陷患者肺隐球菌病的临床影像表现及透明证据分级报告（确诊与假设）
Xiao-Yao Zhang,Hui Ding,Li-Hong Pei et al.
Xiao-Yao Zhang et al.
Introduction. Pulmonary cryptococcosis is increasingly identified in routine care, including among patients with no recorded immunocompromising conditions.Hypothesis/Gap Statement. Real-world descriptions of pulmonary cryptococcosis are dif...
Observational Study
Journal of medical microbiology. 2026 Apr;75(4):002159. DOI:10.1099/jmm.0.002159 2026
Use of TaqMan array card to investigate bacterial isolates in diabetic foot ulcers [0.03%]
应用TaqMan阵列卡片技术检测糖尿病足溃疡中的细菌菌落
Sarah Johnson-Lynn,Martin D Curran,Candice Allen et al.
Sarah Johnson-Lynn et al.
Diabetic foot disease is a major public health problem, with an annual National Health Service (NHS) expenditure exceeding £1 billion. Infection increases the risk of major amputation fivefold. Due to the polymicrobial nature of diabetic f...
Comparable efficacy of bictegravir/emtricitabine/tenofovir alafenamide and doravirine/lamivudine/tenofovir disoproxil fumarate in therapy-naive Human Immunodeficiency Virus adults with very high baseline viraemia [0.03%]
恩曲他滨十替诺福韦铝酯十比克恩丙胺与拉米夫定十富马酸多托伟林磷酯在高病毒载量成人HIV感染者中的疗效可比性研究
Leonardo Calza,Maddalena Giglia,Claudio Rigamonti et al.
Leonardo Calza et al.
Introduction. Clinical trials and observational studies of co-formulated regimens bictegravir/emtricitabine/tenofovir alafenamide (BIC/F/TAF) and doravirine/lamivudine, tenofovir disoproxil fumarate (DOR/3TC/TDF) demonstrated potent efficac...
Comparative Study
Journal of medical microbiology. 2026 Apr;75(4):002119. DOI:10.1099/jmm.0.002119 2026
A comparison of routine blood culture methods and multiplex quantitative PCR for detecting pathogens in simulated polymicrobial blood cultures [0.03%]
检测模拟复杂血流感染病原体的常规血培养和多重qrtpcr方法比较研究
Mariam Doualeh,Christopher Mullally,Martin Thorsen et al.
Mariam Doualeh et al.
Introduction. Polymicrobial bacteraemia, the simultaneous presence of multiple bacterial species in the bloodstream, complicates diagnosis and treatment and is linked to poorer patient outcomes. Accurate detection is essential for effective...
Comparative Study
Journal of medical microbiology. 2026 Apr;75(4):002155. DOI:10.1099/jmm.0.002155 2026
Strain-specific persistence of Burkholderia cenocepacia in the C3HeB/FeJ mouse model of pulmonary infection [0.03%]
分株特异性的Burkholderia cenocepacia在C3HeB/FeJ小鼠肺炎模型中的持续存在性研究
Ziting Chen,Mariana Romero-Gonzalez,Andrea Maser et al.
Ziting Chen et al.
Introduction . Burkholderia cenocepacia, a member of the Burkholderia cepacia complex (Bcc), causes severe, treatment-resistant lung infections in individuals with cystic fibrosis and chronic granulomatous disease.Hypothesis. We hypothesize...
From colonization to invasion: genomic and phenotypic comparison of faecal and bloodstream isolates from the same patients [0.03%]
从殖民化到入侵：来自同一患者的粪便和血液分离株的基因组和表型比较
Aakash Khanijau,Ellie Allman,Ralfh Pulmones et al.
Aakash Khanijau et al.
Introduction. Gram-negative bloodstream infections (GNBSIs) carry a significant global health burden. Escherichia coli and Klebsiella pneumoniae are the two most common causes of healthcare-associated GNBSI, which may arise from gastrointes...
Comparative Study
Journal of medical microbiology. 2026 Apr;75(4):002147. DOI:10.1099/jmm.0.002147 2026
Face mask sampling for the detection of microbes in expelled aerosols and the impact of airway clearance on microbial yield in children with cystic fibrosis: a feasibility trial [0.03%]
儿童囊性纤维化患者呼出气溶胶中微生物的面罩取样检测及支气管扩张对微生物产率的影响：一项可行性试验
Naomi A Dayman,Deepa Patel,Anika Wisniewska et al.
Naomi A Dayman et al.
Background. Early identification of pulmonary exacerbations is vital for the management of cystic fibrosis (CF). Non-invasive airway sampling in preschool children can be inaccurate. Face mask sampling (FMS) is a novel non-invasive approach...
A murine sinonasal infection model recapitulates key features of clinical chronic rhinosinusitis [0.03%]
一种小鼠鼻窦感染模型再现了慢性鼻窦炎的关键临床特征
Emily J Vanderpool,Kendra P Rumbaugh
Emily J Vanderpool
Introduction. Chronic rhinosinusitis is a difficult-to-treat, recurrent inflammatory condition of the nose and paranasal sinuses with global prevalence. Despite its impact on patient quality of life and its cost to the healthcare system, th...
Pre-analytical barriers to blood culture completion in a large laboratory network [0.03%]
大型实验室网络中血培养完成的前分析障碍
Timothy J J Inglis,Teagan F Paton,Benjamin R McFadden et al.
Timothy J J Inglis et al.
Introduction. Sepsis is a major contributor to the global burden of disease. Its effective treatment is time-critical and relies on timely access to significant blood culture (BC) results.Hypothesis/gap statement. The value of BC results to...