PINK1/Parkin-mediated mitophagy is involved in calcium-sensing receptor-induced cardiac damage and apoptosis in spontaneously hypertensive rats [0.03%]
钙敏感受体通过Pink1/parkin介导的线粒体自噬诱导高血压心脏病损伤和凋亡中的作用研究
Siting Hong,Yuanyuan Jin,Yang Li et al.
Siting Hong et al.
Introduction: Hypertension poses a significant threat to human health through its induction of cardiac damage. The calcium-sensing receptor (CaSR) has been implicated in cardiovascular diseases; however, its specific role...
Targeting the Hippo pathway in pulmonary arterial hypertension: emerging pharmacological strategies [0.03%]
肺动脉高压中针对Hippo途径的靶向治疗：新兴的药理学策略
Dangning Zheng,Yanzi Guo
Dangning Zheng
Pulmonary arterial hypertension (PAH) is a severe, progressive disease characterized by pulmonary vascular remodeling and increased resistance, ultimately leading to right heart failure and high mortality. The Hippo signaling pathway has em...
Estrogen treatment restores perivascular adipose tissue -mediated anticontractile effect via NOX4-dependent hydrogen peroxide signaling in ovariectomized hypertensive rats [0.03%]
雌激素治疗通过NOX4依赖的过氧化氢信号途径恢复卵巢切除高血压大鼠的血管外膜脂肪组织抗收缩效应
Bruno C Petroski-Moraes,Isabella Teobaldo Ramos,Jin Hua Sousa et al.
Bruno C Petroski-Moraes et al.
Introduction/aim: Reduced endogenous estrogen increases NADPH oxidase-derived reactive oxygen species (ROS) and promotes vascular dysfunction. Although estrogen treatment restores vascular redox balance, its direct impact...
Characterization of participants with a disproportionate degree of hypertension-mediated organ damage: the Maastricht study [0.03%]
马斯特里赫特研究中高血压靶器官损害程度不一参与者的特征分析
Dellaneira Setjiadi,Christian Delles,Abraham A Kroon et al.
Dellaneira Setjiadi et al.
Background: Although there is a well established link between blood pressure (BP) levels and the severity of hypertension-mediated organ damage (HMOD), some patients with hypertension exhibit a disproportionate degree of ...
Prognostic potential of circulatory miR-19a-3p, miR-19b-3p, and miR-329-3p for future hypertension diagnosis [0.03%]
血清circ miR-19a-3p、miR-19b-3p和miR-329-3p作为未来高血压诊断预测标志物的潜能
Daria Kostiniuk,Antti Blankenstein,Sonja Rajić et al.
Daria Kostiniuk et al.
MicroRNAs have been suggested as essential hypertension biomarkers, but evidence remains inconclusive due to limited high-throughput studies in population cohorts. We analyzed data from the Young Finns Study (YFS) from 2011 and 2018-2020 to...
The theory of hypertensive heart disease and heart failure: revisiting the evidence and pathophysiology [0.03%]
高血压性心脏病与心力衰竭的理论：重新审视证据和病理生理学
Maria Giulia Bellicini
Maria Giulia Bellicini
Background and aim: Arterial hypertension is a major epidemiological risk factor for left ventricular hypertrophy (LVH) and heart failure (HF). Within this framework, the theory of hypertensive heart disease (HHD) has his...
Combined exposure of cold and hypoxia: a driver for hypertension and the underlying role of the microbiota-gut-brain axis [0.03%]
寒冷和低氧的联合暴露：高血压的一个驱动因素及其潜在的肠道微生物-肠-脑轴作用机制
Erkai Zhou,Hao Zhao,Yunhui Yu et al.
Erkai Zhou et al.
Background: Cold and hypoxic conditions often coexist in high-altitude environments and are associated with alterations in blood pressure during short-term exposure. Increasing evidence suggests that the microbiota-gut-br...
Zhe Jiang,Changlin Zhai,Chaojie He et al.
Zhe Jiang et al.
The global population of individuals suffering from hypertension is estimated to surpass 1.28 billion. Uncontrolled hypertension makes contributions to the development of cardiovascular and cerebrovascular diseases. Emerging evidence indica...
Change in blood pressure following transcatheter aortic valve implantation: predictors and association with prognosis [0.03%]
经导管主动脉瓣植入后的血压变化及其预后价值
Alon Kaplan,Viana Copeland,Ehud Regev et al.
Alon Kaplan et al.
Introduction: Aortic stenosis significantly contributes to cardiovascular mortality. While hypertension often coexists with aortic stenosis, the long-term effects of transcatheter aortic valve implantation (TAVI) on blood...
A 25-year longitudinal study on dipping/nondipping tracking in the general population: the PAMELA study [0.03%]
基于一般人群的昼夜血压节律转换长期（25年）队列研究——PALMERAStudy
Cesare Cuspidi,Rita Facchetti,Marijana Tadic et al.
Cesare Cuspidi et al.
Background: The long-term reproducibility of the nighttime blood pressure (BP) phenotypes, namely, dipping (D) and nondipping (ND) has never been described in population-based studies. We investigated this issue in the pa...