Ubiquitination-anchored signature defines neuroendocrine prostate cancer: hub genes and single-cell ecosystem insights from integrated bioinformatics analysis of public transcriptomic datasets [0.03%]
基于泛素化修饰的整合生物信息学分析揭示神经内分泌前列腺癌特征性标志基因及单细胞图谱景观
Zhenkun Zhao,Lei Qiu,Ziang Li et al.
Zhenkun Zhao et al.
Background: Neuroendocrine prostate cancer (NEPC) is an aggressive, treatment-refractory state that often emerges under androgen-receptor pathway inhibition. We hypothesized that dysregulated ubiquitination underpins NEPC...
SPISE index and ensemble machine learning refine cardiovascular risk stratification in stage 0-3 CKM syndrome [0.03%]
基于SPISE指数和集成机器学习细化CKD患者心血管风险分层
Lin Wang,Hao Wang,Ting Liu et al.
Lin Wang et al.
Background: While the single-point insulin sensitivity estimator (SPISE) shows promise as an insulin resistance biomarker, its association with cardiovascular disease (CVD) in early CKM stages (0-3) remains underexplored....
Relationship between Chinese visceral adiposity index and bone mineral density in patients with type 2 diabetes mellitus [0.03%]
中国2型糖尿病患者内脏脂肪指数与骨密度的关系分析
Yuan Ruan,Lei Shi
Yuan Ruan
Background: The relationship between visceral adiposity and bone mineral density (BMD) in type 2 diabetes (T2DM) remains inconsistent, potentially influenced by glycemic control. The Chinese Visceral Adiposity Index (CVAI...
Testosterone deficiency in aging males: a dual threat to vascular and bone health through coronary artery calcification and osteoporosis - a narrative review [0.03%]
老年男性的睾酮缺乏：通过冠状动脉钙化和骨质疏松对血管健康和骨骼健康的双重威胁-叙述性综述
Shijun Li
Shijun Li
Testosterone deficiency, a common condition in aging males, has been increasingly associated with two significant age-related conditions: coronary artery calcification (CAC) and osteoporosis. This comprehensive review examines the current e...
The effect of dutasteride on storage symptoms in men with lower urinary tract symptoms: a REDUCE trial analysis [0.03%]
达鲁司他tidie对下尿路症状性储存症状的影响：取自REDUCE试验的数据分析
Alexander Hernandez-Tirado,Renning Zheng,Eman Dadashian et al.
Alexander Hernandez-Tirado et al.
Background: Dutasteride is used to treat voiding symptoms; its impact on storage symptoms is unclear. Methods: We reviewed 8122 men in ...
Testosterone replacement therapy in older men: skeletal outcomes and fracture risk [0.03%]
老年男性睾酮替代疗法的骨骼结局和骨折风险
Lukasz Szarpak,Mahdi Al-Jeabory,Jaroslaw Pecold et al.
Lukasz Szarpak et al.
Introduction: Testosterone replacement therapy (TRT) is increasingly prescribed to older men with symptomatic testosterone deficiency, yet the balance of musculoskeletal benefits and harms remains uncertain. ...
Narrative-based sexual medicine. A collection of patients' stories and clinical cases to better understand the management of erectile dysfunction with type 5 phosphodiesterase inhibitors in the real life [0.03%]
基于叙事的性医学：一组患者的故事和临床案例，以更好地理解在现实生活中使用第5型磷酸二酯酶抑制剂治疗勃起功能障碍的方法
Andrea Sansone,Raffaella Mantegazza,Shivani Ohri Vignesh et al.
Andrea Sansone et al.
Introduction: Narrative-based medicine (NBM) integrates patient stories with the clinician's perspective and scientific evidence to personalize care. This approach is particularly well suited to sexual medicine. Sexual dy...
Association between circadian syndrome and frailty in middle-aged and elderly people: a longitudinal study [0.03%]
昼夜节律综合征与中老年人衰弱的关系：一项纵向研究
Yingxin Peng,Ningning Dai,Dan Zhao
Yingxin Peng
Background: This study aimed to investigate the cross-sectional and longitudinal associations between Circadian syndrome (CircS) and frailty using nationally representative data from CHARLS (China Longitudinal Study of He...
Exploring the causal links among immune cell characteristics and prostatitis: a bidirectional two-sample Mendelian randomization study [0.03%]
基于双向孟德尔随机化研究探索免疫细胞特征与前列腺炎间的因果关联
Yi Wang,Cong Xue,Zhuxian Xu et al.
Yi Wang et al.
Purpose: We aimed to conduct a bidirectional two-sample Mendelian randomization (MR) analysis to comprehensively explore the causal associations between prostatitis and 731 immune cell properties. ...
An L-shaped curve relating Hs-CRP/HDL-C(CHR) index to kidney stone disease (KSD) in US adult participants: a cross-sectional study [0.03%]
美国成人参与者中与肾结石病(KSD)有关的Hs-CRP/HDL-C(CHR)指数的L形曲线关系：一项横断面研究
Baolei Shi,Wenbing Yuan,Shuangning Liu et al.
Baolei Shi et al.
Using 2015-2020 NHANES data, this cross‑sectional study examined the association between the Hs‑CRP/HDL‑C index (CHR) and adult kidney stone disease (KSD) and its potential nonlinear dose-response pattern. Weighted multivariable logistic...