Extracellular vesicles: potential applications in cancer diagnosis, prognosis, and epidemiology [0.03%]
细胞外囊泡在癌症诊断、预后及病理中的潜在应用
Mukesh Verma,Tram Kim Lam,Elizabeth Hebert et al.
Mukesh Verma et al.
Both normal and diseased cells continuously shed extracellular vesicles (EVs) into extracellular space, and the EVs carry molecular signatures and effectors of both health and disease. EVs reflect dynamic changes that are occurring in cells...
A reliable method for the detection of BRCA1 and BRCA2 mutations in fixed tumour tissue utilising multiplex PCR-based targeted next generation sequencing [0.03%]
一种在固定肿瘤组织中利用多重PCR靶向下一代测序检测BRCA1和BRCA2突变的可靠方法
Gillian Ellison,Shuwen Huang,Hedley Carr et al.
Gillian Ellison et al.
Background: Germline mutations in BRCA1 or BRCA2 lead to a high lifetime probability of developing ovarian or breast cancer. These genes can also be involved in the development of non-hereditary tumours as somatic BRCA1/2...
Length of prostate biopsies is not necessarily compromised by pooling multiple cores in one paraffin block: an observational study [0.03%]
将多块活检组织汇集于同一石蜡切片中，并不会影响前列腺穿刺活检的长度：一项观察性研究
Teemu T Tolonen,Jorma Isola,Antti Kaipia et al.
Teemu T Tolonen et al.
Background: Individually submitted prostatic needle biopsies are recommended by most guidelines because of their potential advantage in terms of core quality. However, unspecified bilateral biopsies are commonly submitted...
Primary gastric actinomycosis: report of a case diagnosed in a gastroscopic biopsy [0.03%]
胃镜活检诊断原发性胃放线菌病1例报告
Khaleel Al-Obaidy,Fatimah Alruwaii,Areej Al Nemer et al.
Khaleel Al-Obaidy et al.
Background: Primary gastric actinomycosis is extremely rare, the appendix and ileocecal region being the most commonly involved sites in abdominopelvic actinomycosis. Herein, we report a case of primary gastric actinomyco...
Case Reports
BMC clinical pathology. 2015 Feb 26:15:2. DOI:10.1186/s12907-015-0002-8 2015
Lara Termini,José H Fregnani,Enrique Boccardo et al.
Lara Termini et al.
Background: Superoxide dismutase-2 (SOD2) is considered one of the most important antioxidant enzymes that regulate cellular redox state in normal and tumorigenic cells. Overexpression of this enzyme in lung, gastric, col...
High Molecular Weight (HMW): total adiponectin ratio is low in hiv-infected women receiving protease inhibitors [0.03%]
人类免疫缺陷病毒阳性并使用蛋白酶抑制剂的妇女中高分子量（HMW）：总脂联素比值较低
Fierdoz Omar,Joel A Dave,Judy A King et al.
Fierdoz Omar et al.
Background: At the time of the study, the HIV-treatment policy in South Africa included highly active antiretroviral therapy (HAART) regimens 1 (nucleotide reverse transcriptase inhibitors (NRTIs) only), and 2 (protease i...
Prognostic value of the MicroRNA regulators Dicer and Drosha in non-small-cell lung cancer: co-expression of Drosha and miR-126 predicts poor survival [0.03%]
Dicer和Drosha的诊断价值：Drosha与miR-126共表达预示非小细胞肺癌预后不良
Kenneth Lønvik,Sveinung W Sørbye,Marit N Nilsen et al.
Kenneth Lønvik et al.
Background: Dicer and Drosha are important enzymes for processing microRNAs. Recent studies have exhibited possible links between expression of different miRNAs, levels of miRNA processing enzymes, and cancer prognosis. W...
Practice of percutaneous needle autopsy; a descriptive study reporting experiences from Uganda [0.03%]
经皮穿刺针式尸体解剖的实践：来自乌干达的经验性描述研究
Janneke A Cox,Robert L Lukande,Sam Kalungi et al.
Janneke A Cox et al.
Background: Percutaneous needle autopsy can overcome a number of barriers that limit the use of complete autopsies. We performed blind-and ultrasound guided needle autopsies in HIV-infected adults in Uganda. In this study...
A putative role for homocysteine in the pathophysiology of acute bacterial meningitis in children [0.03%]
同型半胱氨酸在儿童急性细菌性脑膜炎发病机制中的作用研究
Roney Santos Coimbra,Bruno Frederico Aguilar Calegare,Talitah Michel Sanchez Candiani et al.
Roney Santos Coimbra et al.
Background: Acute bacterial meningitis frequently causes cortical and hippocampal neuron loss leading to permanent neurological sequelae. Neuron death in acute bacterial meningitis involves the excessive activation of NMD...
Estrogen receptor alpha and androgen receptor are commonly expressed in well-differentiated liposarcoma [0.03%]
雌激素受体α和雄激素受体在分化良好的脂肪肉瘤中常见表达
Davis R Ingram,Lloye M Dillon,Dina Chelouche Lev et al.
Davis R Ingram et al.
Background: Liposarcoma (LS) is the second-most common type of soft-tissue sarcoma. Despite advances in knowledge and treatment of this disease, there remains a need for more effective LS therapy. Steroid hormone receptor...