Testing for hereditary thrombophilia: a retrospective analysis of testing referred to a national laboratory [0.03%]
血栓形成倾向遗传学检测的回顾性分析——国家级实验室检测病例分析
Brian R Jackson,Kyland Holmes,Amit Phansalkar et al.
Brian R Jackson et al.
Background: Predisposition to venous thrombosis may be assessed through testing for defects and/or deficiencies of a number of hereditary factors. There is potential for confusion about which of these tests are appropriat...
The calcium-binding protein S100P in normal and malignant human tissues [0.03%]
人正常和恶性组织中的钙结合蛋白S100P
Seppo Parkkila,Pei-Wen Pan,Aoife Ward et al.
Seppo Parkkila et al.
Background: S100P is a Ca2+ binding protein overexpressed in a variety of cancers, and thus, has been considered a potential tumor biomarker. Very little has been studied about its normal expression and functions. ...
Preservation of biomolecules in breast cancer tissue by a formalin-free histology system [0.03%]
无甲醛组织学系统在乳腺癌标本中生物分子的保存研究
Mehdi Nassiri,Sharon Ramos,Hajir Zohourian et al.
Mehdi Nassiri et al.
Background: The potential problems associated with the use of formalin in histology, such as health hazards, degradation of RNA and cross-linking of proteins are well recognized. We describe the utilization of a formalin-...
Biological variability dominates and influences analytical variance in HPLC-ECD studies of the human plasma metabolome [0.03%]
生物变异在HPLC-ECD法测定人类血浆代谢组研究中占主导地位并产生影响
Yevgeniya I Shurubor,Wayne R Matson,Walter C Willett et al.
Yevgeniya I Shurubor et al.
Background: Biomarker-based assessments of biological samples are widespread in clinical, pre-clinical, and epidemiological investigations. We previously developed serum metabolomic profiles assessed by HPLC-separations c...
Low specificity of HIV-testing on sputum specimens kept at ambient temperatures for 4 to 7 days: a blinded comparison [0.03%]
唾液样本在室温下保存4至7天后进行HIV检测的特异性较低：盲法对照研究
Saidi M Egwaga,Timothy M Chonde,Mecky I Matee et al.
Saidi M Egwaga et al.
Background: HIV testing on sputum using the QraQuick HIV1/2(R) assay has high sensitivity and specificity, and holds promise for application in tuberculosis surveys. Its performance under conditions that may occur during ...
An exfoliation and enrichment strategy results in improved transcriptional profiles when compared to matched formalin fixed samples [0.03%]
一种脱皮和丰富策略与匹配的福尔马林固定样品相比可提高转录谱图
Wilfrido D Mojica,Leighton Stein,Lesleyann Hawthorn
Wilfrido D Mojica
Background: Identifying the influence formalin fixation has on RNA integrity and recovery from clinical tissue specimens is integral to determining the utility of using archival tissue blocks in future molecular studies. ...
Levels of oxidative stress biomarkers in seminal plasma and their relationship with seminal parameters [0.03%]
精浆氧化应激生物标志物的水平及其与精液参数的关系
Ali Khosrowbeygi,Nosratollah Zarghami
Ali Khosrowbeygi
Background: There is growing evidence that damage to spermatozoa by reactive oxygen species (ROS) play a key role in male infertility. The aim of the present study was to assess seminal plasma levels of total antioxidant ...
The evaluation of renal ischaemic damage: the value of CD10 monoclonal antibody staining and of biochemical assessments of tissue viability [0.03%]
肾脏缺血损害的评价：CD10单克隆抗体染色和组织活性生化评估的价值
S Tagboto,A Paul Griffiths
S Tagboto
Background: It is well recognised that there is often a disparity between the structural changes observed in the kidney following renal injury and the function of the organ. For this reason, we carried out studies to expl...
The possible role of cell cycle regulators in multistep process of HPV-associated cervical carcinoma [0.03%]
细胞周期调节物在人乳头瘤病毒相关宫颈癌多步骤发生过程中的可能作用
Abeer A Bahnassy,Abdel Rahman N Zekri,Maha Saleh et al.
Abeer A Bahnassy et al.
Background: Human papillomavirus (HPV) 16 and 18 are associated with cervical carcinogenesis through an interaction between HPV oncogenic proteins and cell cycle regulatory genes. However, the exact pathogenetic mechanism...
Rosai-Dorfman disease: a previously unreported association with sickle cell disease [0.03%]
报道首例罗斯-多尔夫曼病与镰状细胞贫血关联的病例报告
Claire Stebbing,Jon van der Walt,Ghada Ramadan et al.
Claire Stebbing et al.
Background: Rosai-Dorfman Disease is an uncommon benign systemic histio-proliferative disease. This is the first time the disease, although more common in people of African descent, is described in association with Sickle...