Ex-vivo changes in amino acid concentrations from blood stored at room temperature or on ice: implications for arginine and taurine measurements [0.03%]
室温或冰上储存血液中的氨基酸浓度变化：对鸟氨酸和牛磺酸测定的意义
Joshua S Davis,Christabelle J Darcy,Kim Piera et al.
Joshua S Davis et al.
Background: Determination of the plasma concentrations of arginine and other amino acids is important for understanding pathophysiology, immunopathology and nutritional supplementation in human disease. Delays in processi...
CD 9 and vimentin distinguish clear cell from chromophobe renal cell carcinoma [0.03%]
CD9和波形蛋白可区分透明细胞肾癌与嫌色性肾癌
Ariel A Williams,John P T Higgins,Hongjuan Zhao et al.
Ariel A Williams et al.
Background: Clear cell renal cell carcinoma (ccRCC) and chromophobe renal cell carcinoma (chRCC) can usually be distinguished by histologic characteristics. Occasionally, diagnosis proves challenging and diagnostic diffic...
Experiences from treatment-predictive KRAS testing; high mutation frequency in rectal cancers from females and concurrent mutations in the same tumor [0.03%]
治疗预测性KRAS检测的经验；女性直肠癌的高突变频率及肿瘤内的并发突变
Mats Jönsson,Anna Ekstrand,Thomas Edekling et al.
Mats Jönsson et al.
Background: KRAS mutations represent key alterations in colorectal cancer development and lead to constitutive EGFR signaling. Since EGFR inhibition represents a therapeutic strategy in advanced colorectal cancer, KRAS mu...
Sedegheh Gharagozlian,Katja Svennevig,Hans-Jacob Bangstad et al.
Sedegheh Gharagozlian et al.
Background: Nephropathy is serious complication of diabetes. We have previously shown that level of the proteoglycan syndecan-1 in blood is associated with ultrastructural kidney changes in young persons with type 1 diabe...
pRb2/p130 protein expression and RBL2 mutation analysis in Burkitt lymphoma from Uganda [0.03%]
乌干达布鲁姆塞瘤中的P130蛋白表达及RBL2基因突变分析
Sam Kalungi,Solrun J Steine,Henry Wabinga et al.
Sam Kalungi et al.
Background: The members of the retinoblastoma protein family, pRb, p107 and pRb2 (p130), are central players in controlling the cell cycle. Whereas disturbed function of pRb is commonly seen in human cancers, it is still ...
Improved methodology for assessment of mRNA levels in blood of patients with FMR1 related disorders [0.03%]
FMR1相关疾病患者血液中mRNA水平评估方法的改进
David E Godler,Danuta Z Loesch,Richard Huggins et al.
David E Godler et al.
Background: Elevated levels of FMR1 mRNA in blood have been implicated in RNA toxicity associated with a number of clinical conditions. Due to the extensive inter-sample variation in the time lapse between the blood colle...
Frank Roels,Patrick Verloo,François Eyskens et al.
Frank Roels et al.
Background: In muscle cytochrome oxidase (COX) negative fibers (mitochondrial mosaics) have often been visualized. Methods: COX activit...
Validation of human papillomavirus genotyping by signature DNA sequence analysis [0.03%]
通过特征DNA序列分析验证人乳头瘤病毒基因型分类
Sin Hang Lee,Veronica S Vigliotti,Jessica S Vigliotti et al.
Sin Hang Lee et al.
Background: Screening with combined cytologic and HPV testing has led to the highest number of excessive colposcopic referrals due to high false positive rates of the current HPV testing in the USA. How best to capitalize...
Performance of the Genotype MTBDRPlus assay in the diagnosis of tuberculosis and drug resistance in Samara, Russian Federation [0.03%]
俄罗斯萨马拉结核病和药物耐受性诊断中基因型MTBDRPlus检测试剂盒性能评估
Vladyslav Nikolayevskyy,Yanina Balabanova,Tatyana Simak et al.
Vladyslav Nikolayevskyy et al.
Background: Russia is a high tuberculosis (TB) burden country with a high prevalence of multidrug resistant tuberculosis (MDRTB). Molecular assays for detection of MDRTB on clinical specimens are not widely available in R...
Molecular analysis of Mycobacterium isolates from extrapulmonary specimens obtained from patients in Mexico [0.03%]
墨西哥患者外肺部标本中分离的分枝杆菌的分子分析
Cosme Alvarado-Esquivel,Nora García-Corral,David Carrero-Dominguez et al.
Cosme Alvarado-Esquivel et al.
Background: Little information is available on the molecular epidemiology in Mexico of Mycobacterium species infecting extrapulmonary sites in humans. This study used molecular methods to determine the Mycobacterium speci...