α-pinene and β-sitosterol co-loaded alginate/gelatin-functionalized niosomes for enhanced antibacterial and anti-biofilm activity against methicillin-resistant Staphylococcus aureus and carbapenem-resistant Klebsiella pneumoniae [0.03%]
负载α-蒎烯和β-谷甾醇的壳聚糖/海藻酸钠-明胶功能化非离子小体对耐甲氧西林金黄色葡萄球菌和碳青霉烯耐药肺炎克雷伯氏菌抗菌及抗生物被膜活性的影响
Hoda Ghoraba,Fatemeh Ashrafi,Rezvan Mousavi Nadushan et al.
Hoda Ghoraba et al.
Background: The rise of antibiotic resistance in infectious disease, particularly from carbapenem-resistant Klebsiella pneumoniae (CRKP) and methicillin-resistant Staphylococcus aureus (MRSA), poses a significant global h...
B3GNT6 suppresses colorectal cancer progression by inhibiting the KRAS/ERK signaling pathway [0.03%]
B3GNT6通过抑制KRAS/ERK信号通路抑制结直肠癌进展
Changwen Jing,Zhuo Wang,Haixia Cao et al.
Changwen Jing et al.
Background: Colorectal cancer (CRC) is one of the most common malignancies with high morbidity and mortality worldwide. B3GNT6 as been predicted to serve as a prognostic indicator for CRC patients, but its biological func...
Affinity enhancement of an anti-VEGF humanized nanobody as a superior candidate to bevacizumab: integrative in silico and in vitro studies [0.03%]
一种增强亲和力的人源化抗VEGF纳米抗体作为贝伐单抗的候选替代品：综合基于计算和体外的研究
Mir Salar Kazemi,Seyed Shahriar Arab,Fatemeh Kazemi-Lomedasht et al.
Mir Salar Kazemi et al.
Background: Although nanobodies have superior characteristics to conventional antibodies, their affinities are often lower because of a single interaction site for antigen binding. Therefore, in the current study, a bioin...
Study on the mesoscopic characteristics of densified forming of shiitake mushroom residue biomass considering particle breakage [0.03%]
基于颗粒破碎的香菇菌渣生物质致密成型介观特性的研究
Hongqiang Wang,Zhen Li,Zhiyu Wang et al.
Hongqiang Wang et al.
The development of biomass pellet fuels represents an important pathway for achieving a low-carbon energy transition. Based on the particle breakage behavior of the feedstock, this study investigated the mesoscopic characteristics of the de...
PAM-flexible SpCas9 variants expand the targeting scope for porcine genome editing and cellular disease modeling [0.03%]
用于猪基因组编辑和细胞疾病建模的PAM灵活的SpCas9变异体扩大了目标范围
Zhiwei Peng,Wenxin Duan,Yuhang Fan et al.
Zhiwei Peng et al.
Background: CRISPR-Cas-mediated gene editing has revolutionized life sciences, yet the targeting scope of the widely used SpCas9 is limited by its strict requirement for the NGG protospacer adjacent motif (PAM). To overco...
Gas vesicle-expressing human pluripotent stem cells enable multimodal ultrasound and optical coherence tomographic imaging [0.03%]
表达气体囊泡的人多能干细胞可实现超声和光学相干层析成像
John Kim,Alessandro R Howells,Sumin Park et al.
John Kim et al.
Genetically encoded imaging reporters are critical tools for tracking cell fate and function in regenerative medicine. Gas vesicles (GVs), air-filled protein nanostructures derived from bacteria, offer unique advantages for noninvasive imag...
Recapitulation of clinical and molecular hallmarks of lipid-induced hepatic insulin resistance in a zonated, vascularized human liver acinus microphysiological system during metabolic dysfunction-associated steatotic liver disease (MASLD) progression [0.03%]
代谢功能紊乱相关性肝脂肪变性疾病(MASLD)进展过程中脂质诱导的肝脏胰岛素抵抗的临床和分子特征在血管化的人肝小叶类器官系统中的再现
Julio Aleman,Lawrence Vernetti,Mark E Schurdak et al.
Julio Aleman et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) impacts ca. 30% of the global population and is very heterogeneous, making it a challenge to develop therapeutics. The heterogeneity arises from genetics, co-morbidities, the ...
Machine learning optimized callogenesis in Justicia gendarussa Burm. f. and phytochemical profiling of in vitro derived callus and leaf extracts [0.03%]
机器学习优化的Justicia gendarussa Burm. f.细胞生成及体外培养衍生的愈伤组织和叶提取物的植物化学成分分析
Nikita Purohit,Deepa Sankar Parasurama
Nikita Purohit
Background: In vitro callus culture systems have been well documented to increase the production of bioactive metabolites. However, optimization of culture conditions through traditional methods consumes time and resource...
An assessment of curcumin, curcumin spanlastics nanoparticles, and curcumin nanocrystals as possible drug delivery systems with antimicrobial, antioxidant, and antitumor activities [0.03%]
姜黄素、姜黄素spanlastics纳米颗粒和姜黄素纳米晶体作为可能的药物递送系统用于抗菌、抗氧化及抗肿瘤作用的评估研究
Jawza A Almutairi,Thanaa A El-Masry,Maisra M El-Bouseary et al.
Jawza A Almutairi et al.
Background: Curcumin is one such polyphenol that has low bioavailability as well as solubility. Therefore, the present study has analyzed, investigated, and estimated the antimicrobial, antioxidant, and anticancer propert...
Antibacterial and antibiofilm activities of curcumin-mediated green-synthesised silver nanoparticles against Methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa [0.03%]
姜黄素介导的绿色合成银纳米颗粒对耐甲氧西林金黄色葡萄球菌和绿脓杆菌的抗菌和抗生物膜活性
Raha Zare Shahraki,Leili Shokoohizadeh,Zahra Chegini et al.
Raha Zare Shahraki et al.