Immunoinformatics-guided design of a multi-epitope vaccine targeting WISP1 for gastric cancer [0.03%]
免疫信息学指导的WISP1多表位胃癌疫苗设计
Negar Mottaghi-Dastjerdi,Behzad Shahbazi,Khadijeh Ahmadi et al.
Negar Mottaghi-Dastjerdi et al.
Background: Gastric cancer remains a leading cause of cancer-related mortality worldwide, and effective preventive or therapeutic vaccines are still lacking. WNT1‑inducible signalling pathway protein 1 (WISP1/CCN4) is a ...
A dual pH/ROS-responsive hyaluronan-gated hollow mesoporous silica nanoplatform with CD44-associated cellular interaction improves curcumin retention under serum challenge and attenuates TNF-α-driven inflammatory outputs in rheumatoid arthritis synovial fibroblasts [0.03%]
一种双重pH/ ROS响应的透明质酸封闭中空介孔二氧化硅纳米平台通过与CD44相关联的细胞相互作用，改善了血清攻击下姜黄素的保留并减弱TNF-α驱动的类风湿性关节炎滑膜成纤维细胞炎症输出
Ni Yan,Elaheh Pilehvar,Sepehr Mehdizadeh et al.
Ni Yan et al.
Rheumatoid arthritis (RA) synovitis is driven in part by activated fibroblast-like synoviocytes derived from rheumatoid arthritis tissue (RA-FLS), which amplify inflammatory and oxidative pathways that contribute to progressive joint damage...
Antimicrobial potential of different bee product-loaded carboxymethyl chitosan nanoparticles against multidrug-resistant clinical pathogens: a comparative in vitro study [0.03%]
载有不同蜂产品羧甲基壳聚糖纳米颗粒的抗菌潜力对抗多重耐药临床病原体：一项比较体外研究
Asmaa K Helmy,Asmaa S El-Houssiny,Ahmed G Hegazi et al.
Asmaa K Helmy et al.
Background: Antimicrobial resistance is one of the major public health threats facing humanity. Hence, the current investigation aimed to develop alternative therapeutic strategies by integrating apitherapy with biopolyme...
Comparative Study
BMC biotechnology. 2026 May 29;26(1):71. DOI:10.1186/s12896-026-01159-5 2026
Unveiling the molecular basis of arsenic resistance in Dietzia maris isolated from arsenic-contaminated soil [0.03%]
从砷污染土壤中分离的Dietzia maris解密耐砷分子机制
Shahid Sher,Rosny Jean,Zaman Khan et al.
Shahid Sher et al.
Background: The highly toxic nature and uncontrolled release of arsenic from anthropogenic activities into ecosystems create a huge health concern globally. Being a class 1 carcinogen, arsenic is affecting billions of peo...
Knockdown of suppressor of glucose by autophagy (SOGA1) alleviates the progression of non-alcoholic steatohepatitis (NASH) by reducing hepatocyte senescence through regulating AMPK/mTOR-mediated mitochondrial homeostasis [0.03%]
自噬介导的葡萄糖抑制因子(SOGA1)敲低通过调节AMPK/mTOR介导的线粒体稳态来延缓非酒精性 steatohepatitis (NASH)进展中的肝细胞衰老
Lijing Yan,Huanhuan Sun,Tianyu Wang et al.
Lijing Yan et al.
Suppressor of glucose by autophagy (SOGA1), a lipid regulator, reprograms energy metabolism in the liver. However, whether SOGA1 is involved in the progression of nonalcoholic steatohepatitis (NASH) remains unclear. In this study, mice were...
Yeast surface display-based screening and preliminary characterization of nectin-4-targeting nanobodies for bladder cancer [0.03%]
基于酵母表面展示技术的nectin-4靶向纳米抗体筛选及初步特性分析用于膀胱癌研究
Jianhua Wen,Liangyi Wei,Jun Huang et al.
Jianhua Wen et al.
Background: Advanced bladder cancer (BCa) is associated with a poor prognosis, highlighting the urgent need for novel therapeutic strategies with improved efficacy and reduced toxicity. Nectin-4 (PVRL4, here after referre...
Anticancer effects of bisabolol oxide A-Loaded Micellar/Liposomal nanoparticles on DU-145 cells with deregulation of miR-34a and miR-181a: in silico and in vitro studies [0.03%]
β-榄香烯载药纳米脂质乳对miR-34a和miR-181a失调的DU-145细胞的抗肿瘤作用：基于计算与实验的研究
Shirin Fekri Kohan,Zohreh Arefi Khorrami,Fatemeh Bahrevar Fatideh et al.
Shirin Fekri Kohan et al.
Bisabolol oxide A, a key bioactive constituent of Matricaria chamomilla, is recognized for its potent anti-inflammatory, antioxidant, and anticancer properties. This study focused on synthesizing bisabolol oxide A-loaded micellar/liposomal ...
Metabolic profiling and systems biology analysis of Flammulina filiformis Fv19 extract: an integrated computational and experimental approach for dual anti-cancer and immunomodulatory therapy [0.03%]
秀珍菇萃取物之代谢路径与系统生物学分析-整合计算与实验方法于抗肿瘤及免疫调节治疗之研究
Heba El-Sayed,Mohamed E Osman,Eslam T Mohamed et al.
Heba El-Sayed et al.
Background: The increasing demand for multi-target cancer therapies has prompted investigation into the anticancer and immunomodulatory potential of the hot water extract of Flammulina filiformis Fv19, utilizing in vitro ...
Ligand-dependent corepressor suppresses angiogenesis and macrophage infiltration in gliobl astoma microenvironment via MCP-1 down-regulation [0.03%]
缺氧诱导的配体结合依赖型核心抑制因子通过下调MCP-1抑制胶质瘤血管生成及巨噬细胞浸润
Shu-Kai Lin,Tai-Qin Li,Xiang-Lan Luo et al.
Shu-Kai Lin et al.
Background: Glioblastoma is one of the most aggressive and lethal forms of brain cancer, characterized by rapid angiogenesis and infiltration of tumor-associated macrophages in the tumor microenvironment (TME). Given the ...
5-Methoxyflavone suppresses nasopharyngeal carcinoma proliferation through regulating p53/SREBP/SCD signaling-mediated lipid synthesis and ferroptosis [0.03%]
5-甲氧基黄酮通过调节p53/SREBP/SCD信号通路介导的脂质合成和铁死亡来抑制鼻咽癌增殖
Yiwen Cui,Yan Zhao,Rong Li et al.
Yiwen Cui et al.
Background: Nasopharyngeal carcinoma (NPC) is a highly prevalent malignant epithelial tumor in southern China. Although early-stage NPC patients have a favorable prognosis with concurrent chemoradiotherapy, the limited ef...