Roger J Pomerantz
Roger J Pomerantz
HIV-1 infection can now be treated effectively in many patients in the developed world, using combination antiretroviral therapeutics, called highly active antiretroviral therapy (HAART). Nevertheless, these regimens do not cure HIV-1 infec...
Varlirix (GlaxoSmithKline) [0.03%]
维瑞可（葛兰素史克）
Ann M Arvin
Ann M Arvin
GlaxoSmithKline (formerly SmithKline Beecham) has developed and launched Varilrix, a preparation of live, attenuated Oka-strain varicella zoster virus, for immunization against varicella zoster infections [455138]. By the end of 1998, Varil...
Alan D T Barrett
Alan D T Barrett
Celltech (formerly Medeva) had developed Arilvax, a single-dose, live, attenuated vaccine for the prevention of yellow fever, which the company launched in Europe. However, in October 2000, PowderJect acquired the vaccine as part of its acq...
Taff Jones
Taff Jones
Celltech Group (formerly Medeva) developed Hepagene, a recombinant polyvalent vaccine with potential activity against hepatitis B virus infections [353474]. In September 2000, PowderJect acquired the product as part of its acquisition of Ce...
Luis M de la Maza,Ellena M Peterson
Luis M de la Maza
Members of the genus, Chlamydia, are obligate intracellular bacteria that have a unique developmental cycle. These organisms are widespread in nature and are common human pathogens. In this review, we describe new data related to the charac...
Meningococcal vaccines [0.03%]
脑膜炎双球菌疫苗
Clare L Collins,Andrew J Pollard
Clare L Collins
Neisseria meningitidis is one of the leading infectious causes of death in children under five years old in industrialized countries, and most cases can be attributed to five disease-causing serogroups: A, B, C, Y and W135. Meningococcal va...
Merrill S Kies,Paul M Harari
Merrill S Kies
ImClone, in collaboration with licensees, Merck KGaA and Bristol-Myers Squibb (BMS), are developing cetuximab, a chimeric monoclonal antibody that blocks the epidermal growth factor receptor, for the potential treatment of various cancers, ...
Ira Pastan,Robert J Kreitman
Ira Pastan
Several antibodies have now been approved for the therapy of cancer. Two of these, rituximab (Rituxan) and alemtuzumab (CAMPATH; ILEX Oncology Inc), are capable of inducing cell death and tumor regressions when given alone. The third, trast...
Wojciech Danysz
Wojciech Danysz
CX-516 is one of a series of AMPA modulators under development by Cortex, in collaboration with Shire and Servier, for the potential treatment of Alzheimer's disease (AD), schizophrenia and mild cognitive impairment (MCI) [234221]. By June ...
New antipsychotic agents for schizophrenia: pharmacokinetics and metabolism update [0.03%]
精神分裂症的新型抗精神病药：药代动力学和代谢更新
Silvio Caccia
Silvio Caccia
The so-called atypical antipsychotics undergo extensive metabolism, except for amisulpride, which is substantially excreted unchanged. Risperidone is oxidized by CYP2D6/CYP3A4 and iloperidone is reduced by cytosolic enzymes, although CYP1A2...