Martin Hewison
Martin Hewison
It is becoming increasingly clear that vitamin D can exert effects on human physiology beyond its long-standing association with skeletal homeostasis. In particular, the ability of active 1,25-dihydroxyvitamin D (1,25(OH)2D) to function as ...
Paul F Smith
Paul F Smith
Parkinson's disease (PD) is a degenerative neurological disorder characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta (SNpc) of the brain. The loss of the dopaminergic projection from the SNpc deprives the...
Tehireem Ahmad,Peter J Barnes,Ian M Adcock
Tehireem Ahmad
Asthma is successfully treated in most patients through the use of conventional corticosteroid therapy. The majority (90 to 95%) of patients respond effectively to moderate doses of inhaled corticosteroids with minimal side effects. Neverth...
PPARbeta/delta ligands as modulators of the inflammatory response [0.03%]
作为炎症反应调节剂的过氧化物酶体增殖激活受体β/δ配体
Kenneth S Kilgore,Andrew N Billin
Kenneth S Kilgore
Peroxisome proliferator-activated receptors (PPARs) are steroid hormone nuclear receptors encoded by three genes: alpha, gamma and beta/delta. Small-molecule agonists of this family of receptors, mostly PPARalpha and PPARgamma agonists, pos...
Shweta Saxena,Manish Banerjee,Raj K Shirumalla et al.
Shweta Saxena et al.
Ceramide 1-phosphate (C1P) possesses emerging and diversified roles in the regulation of various physiological and pathological processes, including cell proliferation, apoptosis and inflammation. Data have established a proinflammatory rol...
Pegloticase, a polyethylene glycol conjugate of uricase for the potential intravenous treatment of gout [0.03%]
聚乙二醇尿酸酶peglocticase用于潜在性静脉注射治疗痛风
Kristen Biggers,Noah Scheinfeld
Kristen Biggers
Savient Pharmaceuticals Inc (formerly Bio-Technology General Corp), under license from Duke University, is developing pegloticase, PEG conjugates of uricase (urate oxidase), for the potential treatment of gout. The in-life portion of the ph...
Raj Padwal
Raj Padwal
Alizyme plc, in collaboration with Takeda Pharmaceutical Co Ltd in Japan, is developing cetilistat, an oral non-absorbed synthetic lipase inhibitor, derived from Alizyme's pancreatic lipase inhibitor research program, for the potential trea...
Alogliptin, a potent and selective dipeptidyl peptidase-IV inhibitor for the treatment of type 2 diabetes [0.03%]
阿洛格列汀，一种有效的二肽基肽酶-Ⅳ抑制剂，用于治疗２型糖尿病
Carolyn F Deacon
Carolyn F Deacon
Takeda San Diego Inc is developing alogliptin, a small-molecule, orally available dipeptidyl peptidase IV (DPP IV) inhibitor, for the potential treatment of type 2 diabetes. In January 2008, Takeda announced that an NDA for alogliptin had b...
Stefano Zucchini
Stefano Zucchini
Human growth hormone (hGH) therapy has been used for the possible improvement of adult height in individuals with idiopathic short stature (ISS) for more than 20 years. However, given its heterogeneity, and the distinction between 'partial'...