Metvix (PhotoCure) [0.03%]
敏维克光动力疗法药物溶液
Kerstin Gardlo,Thomas Ruzicka
Kerstin Gardlo
Metvix is a photosensitive cream containing the methyl ester of 5-aminolevulinic acid, which has been developed and launched by PhotoCure in Sweden for the treatment of high-risk basal cell carcinoma and actinic keratosis.
ONT-093 (Ontogen) [0.03%]
ONT-093(ONTG-093)
Prakash Mistry,Adrian Folkes
Prakash Mistry
Ontogen is developing ONT-093 (formerly OC-144-093), a P-glycoprotein pump inhibitor, for the potential reversal of multidrug resistance in patients undergoing cancer chemotherapy. The compound is also being evaluated for its potential enha...
Dietmar W Siemann,Michael R Horsman
Dietmar W Siemann
The tumor vessel support network offers a tantalizing target for cancer therapy, given the complete dependence of a solid neoplasia on the vasculature for both the delivery of oxygen and other nutrients, as well as the effective removal of ...
Gregory D Leonard,Orsolya Polgar,Susan E Bates
Gregory D Leonard
P-glycoprotein (P-gp), a plasma membrane pump associated with multidrug resistance (MDR), is a member of the superfamily of ATP-binding cassette (ABC) transporters. The discovery that inhibitors of drug efflux can increase drug accumulation...
Flaminio Cattabeni
Flaminio Cattabeni
Boston Life Sciences (BLS) is developing Altropane as a potential radio-imaging agent to be used with single photon emission tomography (SPECT), for the early diagnosis of Parkinson's disease (PD) and attention deficit hyperactivity disorde...
Hans Jürgen von Giesen,Gabriele Arendt
Hans Jürgen von Giesen
The manifestation of HIV-1-associated minor motor deficits or HIV-1-associated dementia indicates viral activity within the CNS. Highly active antiretroviral therapy (HAART) has a prophylactic effect, which does not protect all patients, be...
Role of CRH in the pathogenesis of dementia of Alzheimer's type and other dementias [0.03%]
CRH在阿尔茨海默病型痴呆和其他痴呆发病机制中的作用
Habib U Rehman
Habib U Rehman
This review focuses on the role of corticotrophin-releasing hormone (CRH) in the pathogenesis of Alzheimer's disease (AD) and briefly discusses its role in other dementias, including Parkinson's disease (PD), progressive supranuclear palsy ...
Thomas G Beach
Thomas G Beach
Overproduction of the peptide amyloid beta (Abeta) is a critical pathogenic event in Alzheimer's disease (AD), leading to the formation of amyloid plaques, neurofibrillary tangles, synaptic loss and dementia. Decreasing Abeta production may...
Nayahmka J McGriff-Lee
Nayahmka J McGriff-Lee
Cellegy is developing a drug delivery system designed to facilitate the transdermal and topical delivery of testosterone for the potential treatment of male hypogonadism (as Tostrex) and decreased sexual energy in post-menopausal women (asT...
Stephan Francke
Stephan Francke
TAK-677 is a beta3-adrenergic agonist under development by Dainippon and Takeda for the potential treatment of non-insulin dependent diabetes and obesity. In March 2001, Takeda initiated a phase II trial in the US for Type II diabetes [4118...