AL-108 and AL-208, formulations of the neuroprotective NAP fragment of activity-dependent neuroprotective protein, for cognitive disorders [0.03%]
神经活性依赖性神经保护蛋白片段NAP的神经保护剂AL-108和AL-208治疗认知障碍
Hugo Geerts
Hugo Geerts
Allon Therapeutics Inc is developing AL-108, an intranasally administered, eight-amino-acid peptide fragment (known as NAP) of activity-dependent neuroprotective protein, and AL-208, an intravenous formulation of NAP. AL-108 is undergoing p...
Morphine-6-glucuronide, an active morphine metabolite for the potential treatment of post-operative pain [0.03%]
吗啡-6-葡萄糖醛酸，一种潜在治疗术后疼痛的活性吗啡代谢物
Girish P Joshi
Girish P Joshi
Morphine-6-glucuronide (M6G) is an active metabolite of morphine that is being developed by CeNeS Pharmaceuticals as an alternative to morphine (the most commonly used opioid) for the management of postoperative pain. M6G is currently under...
Casopitant, a neurokinin-1 receptor antagonist with anti-emetic and anti-nausea activities [0.03%]
是一种神经激肽-1受体拮抗剂的卡索泮具有止吐和止恶心活性
Rudolph M Navari
Rudolph M Navari
Casopitant, an inhibitor of the neurokinin-1 receptor, and its mesylate salt, are being developed by GlaxoSmithKline plc for the potential treatment of chemotherapy-induced nausea and vomiting (CINV), post-operative nausea and vomiting (PON...
Elena Choleris,Amy E Clipperton,Anna Phan et al.
Elena Choleris et al.
Neurobehavioral investigations into the functions of estrogen receptor (ER)alpha and ERbeta have utilized 'knockout' mice, phytoestrogens and, more recently, ER-specific agonists. Feeding, sexual, aggressive and social behavior, anxiety, de...
Martin M Bednar
Martin M Bednar
The structural underpinning responsible for neuroplasticity and neurorestoration under physiological and pathophysiological conditions is only beginning to be elucidated. It is evident that life-long neurogenesis occurs in the human brain, ...
Andrea L O Hebb,Harold A Robertson
Andrea L O Hebb
PDEs are important second messenger systems governing a host of cellular functions involved in neural signal transduction in the CNS and inflammatory cell signaling in the immune system. The contributions of PDE family members as novel trea...
Sarah K Orr,Richard P Bazinet
Sarah K Orr
Epidemiological studies have linked fish consumption to lower rates of neurological diseases. Fish contains high levels of omega-3 polyunsaturated fatty acids (n-3 PUFA), and several lines of evidence suggest that the n-3 PUFA docosahexaeno...
Edgar Alfonso Romero-Sandoval,Ryan J Horvath,Joyce A DeLeo
Edgar Alfonso Romero-Sandoval
Chronic pain is the most difficult type of pain to treat. Previously, the development of analgesics has focused on neuronal targets; however, current analgesics are only modestly effective, have significant side effects and do not provide u...
Jill-Desiree Brederson,Michael F Jarvis
Jill-Desiree Brederson
ATP contributes to nociceptive sensory processing by activating a family of ligand-gated ion channels, the P2X receptors. One of these, the P2X3 receptor, is highly localized on primary afferent neurons. In sensory neurons, P2X3 receptors f...
Francesco Belardetti,Gerald W Zamponi
Francesco Belardetti
Voltage-gated calcium channels underlie a plethora of physiological functions in the cardiovascular and nervous systems. Calcium channels are considered important targets for the treatment of conditions such as absence epilepsy and hyperten...