Tolevamer, an orally administered, toxin-binding polymer for Clostridium difficile-associated diarrhea [0.03%]
Noah Scheinfeld,Kristen Biggers
Noah Scheinfeld
Genzyme Corp is developing tolevamer, an anionic toxin-binding polymer that binds and neutralizes the Clostridium difficile A and B toxins, for the potential treatment of C difficile-associated diarrhea (CDAD). Two phase III clinical trials...
Rilpivirine, a non-nucleoside reverse transcriptase inhibitor for the treatment of HIV infection [0.03%]
Diego Ripamonti,Franco Maggiolo
Diego Ripamonti
Tibotec BVBA is developing the diarylpyrimidine rilpivirine, a second-generation non-nucleoside reverse transcriptase inhibitor for the potential treatment of HIV infection. A phase III trial of rilpivirine in HIV-infected, treatment-naive ...
Cecilia Cabrera
Cecilia Cabrera
Merck & Co has developed and launched raltegravir, an HIV-1 integrase inhibitor for the treatment of HIV-1 infection in treatment-experienced adult patients who have evidence of viral replication and HIV-1 strains resistant to multiple anti...
Florian Weis,Andres Beiras-Fernandez,Gustav Schelling
Florian Weis
Gram-positive cocci are one of the leading causes of infections in clinical medicine. Since the invention of antibiotic substances, multidrug resistance is a major problem in the treatment of such infections. Methicillin-resistant Staphyloc...
Ioanna P Korbila,Matthew E Falagas
Ioanna P Korbila
Bloodstream infections, especially those arising from multidrug-resistant strains, are an alarming public health threat requiring continuous efforts for new drug development. In this review, antibiotics at an advanced development stage for ...
Yuk-Ching Tse-Dinh
Yuk-Ching Tse-Dinh
The smallpox virus can potentially be used as a biological weapon and pose a serious threat to human populations, thus rendering the development of measures against it particularly important. There is a lack of effective antiviral drugs for...
Robert J Bastidas,Jennifer L Reedy,Helena Morales-Johansson et al.
Robert J Bastidas et al.
Microbes evolved to produce natural products that inhibit growth of competing soil microorganisms. In many cases these compounds act on fungi, which are eukaryotes with conserved gene sequences closely related to metazoans, including humans...
Marta Wroblewska
Marta Wroblewska
Respiratory viruses are important human pathogens, affecting both healthy individuals and immunocompromised patients. In the past decade several new human respiratory viruses have been described, some of which have the potential to start an...
Ralph A Tripp,S Mark Tompkins
Ralph A Tripp
The influenza virus causes significant morbidity and mortality annually. Vaccination is currently the most effective measure to prevent influenza-related illness, however, current vaccine technologies face annual problems with vaccine-strai...
Taff Jones
Taff Jones