Atacicept, a homodimeric fusion protein for the potential treatment of diseases triggered by plasma cells [0.03%]
用于治疗浆细胞引发的疾病的药物阿塔西西普（融合蛋白）
Barbara Gatto
Barbara Gatto
Atacicept (TACI:Fc5) is a homodimeric fusion protein obtained through recombinant DNA technology being developed by Merck Serono SA, under license from ZymoGenetics Inc, for the potential treatment of B-cell diseases. Atacicept is undergoin...
Ocrelizumab, a humanized monoclonal antibody against CD20 for inflammatory disorders and B-cell malignancies [0.03%]
抗CD20人源化单克隆抗体奥瑞珠单抗用于炎症性疾病和B细胞恶性肿瘤
Gabor Hutas
Gabor Hutas
Biogen Idec Inc, Genentech Inc, Roche Holding AG and Chugai Pharmaceutical Co Ltd are developing ocrelizumab, a humanized mAb against CD20, for the potential treatment of inflammatory disorders and B-cell malignancies. Ocrelizumab is underg...
The role of sphingosine-1-phosphate and ceramide-1-phosphate in calcium homeostasis [0.03%]
鞘氨醇-1-磷酸和神经酰胺-1-磷酸在钙稳态中的作用
Vania Hinkovska-Galcheva,Susan M VanWay,Thomas P Shanley et al.
Vania Hinkovska-Galcheva et al.
During the last several years, sphingolipids have been identified as a source of important signaling molecules. Particularly, the understanding of the distinct biological roles of ceramide, sphingosine-1-phosphate (S1P), ceramide-1-phosphat...
IgE and immunoglobulin free light chains in allergic disease: new therapeutic opportunities [0.03%]
IgE和免疫球蛋白轻链在过敏性疾病中的作用：新的治疗机会
Frank A Redegeld,Cornelis H Wortel
Frank A Redegeld
The prevalence of allergy and associated diseases has dramatically increased during the last few decades. These hypersensitivity reactions can be subdivided into IgE- and non-IgE-dependent diseases. Anti-IgE approaches, such as omalizumab, ...
Therapeutics targeting IL-13 for the treatment of pulmonary inflammation and airway remodeling [0.03%]
针对IL-13的治疗肺部炎症和气道重塑的药物疗法研究进展
Kate Blease
Kate Blease
Targeting the IL-13 pathway appears to be a viable approach to ameliorate pulmonary inflammation and remodeling. Support for this hypothesis comes from preclinical and preliminary clinical data. Diverse approaches have been used to target t...
Talmadge E King Jr
Talmadge E King Jr
Idiopathic pulmonary fibrosis (IPF) is a debilitating, fatal, chronic fibrosing lung disease with no known effective therapy. Endothelin-1 may underlie the pathogenesis of lung fibrosis, therefore it was hypothesized that the oral dual endo...
Rujun Gong
Rujun Gong
Hepatocyte growth factor (HGF) is a paracrine multifunctional pleiotropic cytokine. HGF has demonstrated potent anti-inflammatory activity in several animal models of disease and multiple organ systems. HGF suppresses inflammation by target...
Brian J Van Lenten,Mohamad Navab,G M Anantharamaiah et al.
Brian J Van Lenten et al.
Apolipoprotein mimetic peptides dramatically reduce atherosclerosis in animal models, and may be an excellent mode of therapy to treat a variety of vascular inflammatory conditions, including atherosclerosis. Studies of apolipoprotein mimet...
NSAID-induced gastrointestinal damage and the design of GI-sparing NSAIDs [0.03%]
非甾体抗炎药致胃肠损伤及研发保护胃肠道的非甾体抗炎药
John L Wallace,Linda Vong
John L Wallace
NSAIDs are among the most widely used medications, but the side effects of these drugs frequently include gastrointestinal (GI) ulceration and bleeding. COX-2 inhibitors were designed that were claimed to be devoid of ulcer-promoting effect...
Neuroinflammatory diseases and the importance of a healthy blood-brain barrier [0.03%]
神经炎症性疾病与健康血脑屏障的重要性
Mariano J Elices
Mariano J Elices