Multidrug-resistant Gram-negative bacterial infections: the emerging threat and potential novel treatment options [0.03%]
多重耐药革兰氏阴性菌感染：迫在眉睫的威胁及潜在新型治疗选择
Paschalis I Vergidis,Matthew E Falagas
Paschalis I Vergidis
Gram-negative bacterial infections constitute an emerging threat because of the development of multidrug-resistant organisms. There is a relative shortage of new drugs in the antimicrobial development pipeline that have been tested in vitro...
Eleanor Day,Karen Buckberry,Michael R Sharland et al.
Eleanor Day et al.
The development of effective antiretroviral therapy for HIV has led to significant virological suppression and immune reconstitution, and resulted in dramatic reductions in HIV-related morbidity and mortality. However, in children initial r...
Osmond J D&#x;Cruz,Faith M Uckun
Osmond J D&#x;Cruz
The most common mode of acquiring HIV-1 is via sexual transmission across the genital mucosa. Topical microbicides are a promising prevention strategy for the protection against HIV infection and may ultimately have an impact on the global ...
Norovirus gastroenteritis, increased understanding and future antiviral options [0.03%]
诺如病毒胃肠炎：进一步认识和未来抗病毒选择
Ming Tan,Xi Jiang
Ming Tan
Increasing epidemiological data indicate that norovirus is an important cause of acute gastroenteritis. Norovirus gastroenteritis is difficult to control owing to its widespread nature and the lack of a suitable antiviral agent or a vaccine...
Graciela Andrei,Eric De Clercq,Robert Snoeck
Graciela Andrei
Human CMV (HCMV) is an opportunistic pathogen associated with significant morbidity and mortality among immunocompromised patients (in particular immunosuppressed patients with stem cell or solid organ transplantation, AIDS or cancer). Addi...
Nicholas A Meanwell,George W Koszalka
Nicholas A Meanwell
Seletracetam, a small molecule SV2A modulator for the treatment of epilepsy [0.03%]
一种用于治疗癫痫的新型SV2A调节剂小分子塞利拉塞tramButtonTitles
John R Pollard
John R Pollard
UCB SA was developing the high-affinity synaptic vesicle glycoprotein 2A ligand, seletracetam, an analog of levetiracetam, for the potential oral treatment of epilepsy. Phase II epilepsy trials were underway, but in July 2007, the company s...
Methylnaltrexone, a new peripheral mu-receptor antagonist for the prevention and treatment of opioid-induced extracerebral side effects [0.03%]
用于预防和治疗阿片类药物引起的周围性副反应的一种新型外周μ-受体拮抗剂甲基纳曲酮
Florian M Reichle,Peter F Conzen
Florian M Reichle
Progenics Pharmaceuticals Inc and Wyeth Pharmaceuticals are developing methylnaltrexone, a micro-receptor opioid antagonist derived from naltrexone by the addition of a methyl group. The intravenous formulation of methylnaltrexone is curren...
The role of tetrodotoxin-resistant sodium channels in pain states: are they the next target for analgesic drugs? [0.03%]
参与疼痛状态的耐四聚毒素钠通道：会成为镇痛药的下一个靶点吗？
Inmaculada Silos-Santiago
Inmaculada Silos-Santiago
Neuropathic pain, a persistent chronic pain resulting from damage to the central or peripheral nervous system, is a condition that severely affects the quality-of-life of millions of individuals worldwide. The treatment of neuropathic pain ...
Paul F White
Paul F White
Postoperative pain is a complex and multifactorial symptom that requires a thoughtful approach using a variety of treatment modalities to obtain an optimal outcome after surgery. Multimodal (or 'balanced') analgesia represents an approach t...