M Ian Phillips,Shuntaro Kagiyama
M Ian Phillips
Angiotensin II (Ang II), the most important component of the renin-angiotensin system, is usually associated with hypertension and renal failure. Through its pro-inflammatory actions, it also plays an important role in each step of the deve...
Max Reinshagen,Georg von Boyen,Guido Adler et al.
Max Reinshagen et al.
Until now neurotrophins like nerve growth factor (NGF), brain-derived neurotrophic factor (BDNA), neurotrophin (NT)-3 and neurotrophic factors like glial-derived neurotrophic factor (GDNF) have been almost exclusively investigated concernin...
Dirk Seegert,Stefan Schreiber
Dirk Seegert
Sevtap Arikan,John H Rex
Sevtap Arikan
Eisai and Bristol-Myers Squibb (BMS) are developing the triazole, ravuconazole, as a potential treatment for fungal infection [187888]. Eisai selected the compound for further development on the basis of its good safety profile and well-bal...
Miltefosine Zentaris [0.03%]
米替福新(Zentaris)
Ronald Kaminsky
Ronald Kaminsky
Zentaris (formerly Asta Medica) has developed and launched miltefosine, a phospholipid derivative, in various European countries [173324], [254947] and in Brazil in 1997 [332428], [366795] as a treatment for breast cancer. As of January 200...
Artemotil Artecef [0.03%]
阿特莫替林左旋体
Rodney A Yeates
Rodney A Yeates
The ethyl ether derivative of artemesinin, artemotil, has been developed by Artecef for the potential treatment of malaria. Adult and pediatric intramuscular formulations of the product were filed for approval in The Netherlands in January ...
Tracy Garnier,Simon L Croft
Tracy Garnier
Parenteral pentavalent antimonials remain the standard therapy for cutaneous leishmaniasis. More effective and patient-compliant topical treatments are an important alternative treatment for the localized self-limiting forms of this disease...
Antibiotics for the treatment of onchocerciasis and other filarial infections [0.03%]
抗生素治疗河盲症及其他丝虫感染
Achim Hoerauf,Ohene Adjei,Dietrich W Büttner
Achim Hoerauf
More effective drugs are needed for the treatment of human filarial diseases and the elimination of these infections as a public health problem. The drugs must either kill or sterilize adult worms. The relevant filariae, Onchocerca volvulus...
Saibal Dey
Saibal Dey
Vertex is developing biricodar as a chemosensitizing agent designed to restore the effectiveness of chemotherapeutic agents in tumor multidrug resistance. By November 1998, phase II trials had commenced for biricodar, in combination with ch...
Wilfred D Stein
Wilfred D Stein
Multidrug resistance can arise from the presence of the membrane-bound pump, P-glycoprotein, in a tumor. Major efforts have been made to develop inhibitors of this pump, and a number of promising blockers have reached late stages of clinica...