Historical perspectives in clinical pathology: Bence Jones protein-early urine chemistry and the impact on modern day diagnostics [0.03%]
临床病理学中的历史视角：Bence-Jones蛋白-早期尿化学及其对现代诊断的影响
Sheromna Sewpersad,Tahir S Pillay
Sheromna Sewpersad
This is the third in the series of historical articles dealing with developments in clinical pathology. Bence Jones proteins are immunoglobulin light chains found in excessive quantities in urine in multiple myeloma and are believed to be o...
Significance of PI3K signalling pathway in clear cell renal cell carcinoma in relation to VHL and HIF status [0.03%]
VHL和HIF状态相关的PI3K信号通路在透明细胞肾细胞癌的意义
Raviprakash Tumkur Sitaram,Maréne Landström,Göran Roos et al.
Raviprakash Tumkur Sitaram et al.
Renal cell carcinoma (RCC) includes diverse tumour types characterised by various genetic abnormalities. The genetic changes, like mutations, deletions and epigenetic alterations, play a crucial role in the modification of signalling networ...
Reduced sensitivity for EGFR T790M mutations using the Idylla EGFR Mutation Test [0.03%]
Idylla EGFR突变检测用于T790M突变检测的敏感度降低
Eric Lee,Victoria Jones,Eleni Topkas et al.
Eric Lee et al.
Aims: Osimertinib is a third-generation EGFR (epidermal growth factor receptor) tyrosine kinase inhibitor that is effective in non-small cell lung cancer (NSCLC) harbouring the EGFR T790M mutation. The Idylla EGFR Mutatio...
Performance of gastrointestinal pathologists within a national digital review panel for Barrett's oesophagus in the Netherlands: results of 80 prospective biopsy reviews [0.03%]
荷兰巴雷特食管国家级数字审查委员会内胃肠病理医师的表现：80例前瞻性活检结果分析
Esther Klaver,Myrtle van der Wel,Lucas Duits et al.
Esther Klaver et al.
Aims: The histopathological diagnosis of low-grade dysplasia (LGD) in Barrett's oesophagus (BO) is associated with poor interobserver agreement and guidelines dictate expert review. To facilitate nationwide expert review ...
Naoko Yamaguchi,Utano Tomaru,Takayuki Kiuchi et al.
Naoko Yamaguchi et al.
Aim: Cathepsins are proteases that regulate a wide range of physiological processes, including protein turnover, cell signalling and antigen presentation. Recent studies have shown that cathepsins are highly upregulated i...
Sanjay A Pai,Sanjeev V Katti
Sanjay A Pai
Miguel Garcia Pardo,Inmaculada Aparicio,Marta Arregui et al.
Miguel Garcia Pardo et al.
Umberto Malapelle,Caterina De Luca,Antonino Iaccarino et al.
Umberto Malapelle et al.
Aims: In the time of COVID-19, predictive molecular pathology laboratories must still timely select oncological patients for targeted treatments. However, the need to respect social distancing measures may delay results g...
Viropathic multinuclear syncytial giant cells in bronchial fluid from a patient with COVID-19 [0.03%]
新型冠状病毒患者的支气管液中的多核巨细胞
Sylvia Stadlmann,Robert Hein-Kuhnt,Gad Singer
Sylvia Stadlmann
The role of the Clinical Chemistry laboratory in facilitating earlier diagnosis of dyslipidaemia-associated inherited metabolic disease [0.03%]
临床化学实验室在提早诊断血脂异常相关遗传性代谢疾病中的作用
Janice Lv Reeve,Patrick J Twomey,Ingrid Borovickova
Janice Lv Reeve