Mesenchymal neoplasms with RAF/BRAF alterations: eight cases revealing novel fusions, V600E mutation and clonal evolution [0.03%]
带有RAF/BRAF改变的间质源性肿瘤：八种新融合、V600E突变和克隆演变病例的研究
Xiaolong Feng,Xianming Huang,Weiwei Hao et al.
Xiaolong Feng et al.
Objective: While kinase-altered spindle cell tumours were classically recognised in paediatric superficial soft tissues, recent literature indicates an expanding clinicopathologic spectrum. This study investigates a cohor...
Validation of polymerase chain reaction-indexed next-generation sequencing assay on the Illumina iSeq 100 platform for MPL exon 10 mutation detection: a robust alternative to Sanger sequencing [0.03%]
用于检测MPL外显子10突变的PCR索引NGS和桑格测序对比研究：一种稳健的二代测序平台及检测试剂盒
Dilys Lau,Janice Yen Qi Loo,Sau-Yoke Ng et al.
Dilys Lau et al.
Liver disease diagnostics and access barriers in African settings: a narrative review [0.03%]
非洲地区肝脏疾病诊断及诊疗障碍的相关叙述性综述研究
Habiblah Ayomide Jagunmolu,Emmanuel Oyedeji Oyetola,Yusuff Abiola Lawal et al.
Habiblah Ayomide Jagunmolu et al.
In Africa, chronic liver conditions are discordantly higher due to infectious and parasitic aetiologies, especially viral hepatitis. Early diagnosis is a linchpin for successful management and improved outcomes; however, diagnostic power is...
Digital diagnostic pathology between promise and professional erosion: artificial intelligence and the future of diagnostic sovereignty [0.03%]
数字化诊断病理学在承诺与专业削弱之间：人工智能与诊断主权的未来
Glen Kristiansen
Glen Kristiansen
Contextual interpretation of luminal phenotype in low-grade breast epithelial proliferations [0.03%]
低级别乳腺上皮增生的腔谱型的 contextual 诠释
Emad A Rakha
Emad A Rakha
Diagnosing low-grade intraductal epithelial proliferations and distinguishing hyperplasia from neoplasia has traditionally relied on well-established morphological and immunophenotypic criteria. However, in routine practice, differentiating...
Myeloid-derived suppressor cells in anaplastic thyroid carcinoma: insights from prospective immune profiling and implications for targeted immunotherapy [0.03%]
肉瘤样分化型甲状腺癌中髓系源抑制性细胞的免疫表型及免疫治疗研究
Monikongkona Boruah,Shipra Agarwal,Riyaz Ahmad Mir et al.
Monikongkona Boruah et al.
Purpose: Anaplastic thyroid carcinoma (ATC) exhibits limited responsiveness to immunotherapy. The current study characterises the immune cell repertoire in ATC compared with differentiated thyroid carcinoma (DTC) and thyr...
Concordance of conventional two-tier HER2 classification versus three-tier classification (including HER2-low status) in invasive breast carcinoma: a retrospective real-world analysis [0.03%]
传统的两分法HER2分类与包括HER2低表达状态的三分法分类在浸润性乳腺癌中的符合率：一项回顾性的、真实世界的研究分析
Archita Juneja,Ayushi Sahay,Pooja Padwale et al.
Archita Juneja et al.
Aim: To compare changes in HER2 expression status on reassessment across multiple clinical groups using new three-tier versus traditional binary HER2 reporting schemas. ...
Digital Ki-67 quantification in neuroendocrine tumours: comparing performance of camera-captured images and open-source platforms across imaging modalities [0.03%]
数字Ki-67在神经内分泌肿瘤中的量化：比较相机捕获图像和开源平台跨成像模式的性能
Nandan Padmanabha,Ruben Oganesyan,Laurie O&#x;brien et al.
Nandan Padmanabha et al.
Aims: Accurate assessment of the Ki-67 proliferation index (PI) is essential for grading and prognostication of gastrointestinal well-differentiated neuroendocrine tumours (NETs). While manual counting (MC) of 500-2000 tu...
Reporting of both positive and negative concordance is necessary to recognise and investigate bias in digital algorithms [0.03%]
为了识别和调查数字算法中的偏见，需要报告一致的正面和负面情况
Megan L Troxell,Cansu Karakas,Maggie M Lam et al.
Megan L Troxell et al.
UK participation in the UK National External Quality Assessment Scheme for mismatch repair immunohistochemistry: insights from the last decade [0.03%]
英国参与英国国家外部质量评估计划的错配修复免疫组化项目：过去十年的启示
Luke Ar Farmkiss,Andrew Dodson,Suzanne Parry et al.
Luke Ar Farmkiss et al.
Aim: Comparison of immunohistochemical detection of mismatch repair (MMR) proteins within tumours, as deficient MMR is important for (1) the detection of Lynch Syndrome, caused by inherited variants affecting the DNA MMR ...