Defining biochemical, pathological and molecular factors prognostic in terms of disease control and survival in high-grade extremity soft tissue sarcoma: a scoping review [0.03%]
高分级软组织肉瘤的生化、病理和分子预后因素的界定：一种综述性研究
Kiara Peirens,David Creytens,Fleur Cordier et al.
Kiara Peirens et al.
Aims: High-grade extremity soft tissue sarcomas (eSTS) are rare, heterogeneous malignancies with a high metastatic potential. Prognostic assessment remains challenging due to wide variation in outcomes. Current risk strat...
MILGDF: a multi-task, instance-level supervised model for oral squamous cell carcinoma integrating local-global attention and dynamic decision fusion [0.03%]
结合局部全局注意力和动态决策融合的多任务、实例级监督模型MILGDF用于口腔鳞状细胞癌
Chen-Xi Li,Yan Chen,Liang-Hui Xu et al.
Chen-Xi Li et al.
Aims: This research was designed to establish an innovative diagnostic strategy employing whole-slide imaging (WSI) technology to address the diagnostic difficulties arising from the intricate histological architecture an...
Paediatric B-lymphoblastic leukaemia with low peripheral blasts: a potential diagnostic pitfall [0.03%]
儿科B淋巴母细胞白血病外周血幼稚细胞少：一种潜在的诊断陷阱
Emily M Harris,Matthew M Heeney,Andrew E Place et al.
Emily M Harris et al.
B cell acute lymphoblastic leukaemia (B-ALL) infrequently presents with undetectable or very low peripheral blood (PB) lymphoblasts, which may cause diagnostic difficulties. We report the clinicopathological features of paediatric patients ...
MRI-targeted versus systematic needle core biopsies in prostate cancer: a patient-based analysis of potential diagnostic and biologic underestimation [0.03%]
基于患者的分析：前列腺癌 MRI 目标针芯活检与系统性针芯活检在潜在诊断和生物学低估方面的差异
Faisal Saeed,Adeboye O Osunkoya
Faisal Saeed
Aims: MRI-targeted needle core biopsy (MRI-NCB) improves detection of clinically significant prostate cancer (csPCa), but whether it can replace systematic ultrasound-guided biopsy (US-NCB) remains debated, as most studie...
Basal plasmacytosis and eosinophilia for distinguishing inflammatory bowel disease from gastrointestinal tuberculosis on mucosal biopsy [0.03%]
黏膜活检基底浆细胞增多和嗜酸性粒细胞增多用于鉴别炎症性肠病与肠道结核
Sagir Akhtar,Lalita Mehra,Mridul Mahajan et al.
Sagir Akhtar et al.
Aims: Accurate distinction of inflammatory bowel disease (IBD) and gastrointestinal tuberculosis (GITB) on mucosal biopsies remains challenging, especially in South-East Asia. Our previous meta-analysis highlighted that m...
Assay-dependent variability in free thyroxine (FT4): differential interference related to immunoassay design in a patient with subclinical hypothyroidism [0.03%]
亚临床甲状腺功能减退患者游离甲状腺素(FT4)的检测依赖性变异：免疫测定设计相关的差异干扰
Cindy Lt Lum,Wei Lin Tay,Brenda Sm Chiang et al.
Cindy Lt Lum et al.
In clinical practice, thyroid function tests (TFTs) usually comprise thyroid-stimulating hormone (TSH) and free thyroxine (FT4), with free triiodothyronine (FT3) measured less frequently. We report a 76-year-old woman with autoimmune thyroi...
Microbiological characteristics of granulomatous lobular mastitis revealed by metagenomic sequencing [0.03%]
基于元基因组测序的肉芽肿性小叶乳腺炎微生物特征分析
Yirui Diao,Jianrong Li,Luyao Wang et al.
Yirui Diao et al.
Aims: Granulomatous lobular mastitis (GLM) is a rare, chronic, benign inflammatory disease of the breast with an unclear aetiology. This study aimed to characterise the microbial features of GLM using metagenomic next-gen...
Secondary BRAF-mutated histiocytic/dendritic cell sarcoma transdifferentiated from follicular lymphoma with prolonged response to BRAF/MEK inhibition and subsequent evolution to high-grade B-cell lymphoma [0.03%]
由滤泡性淋巴瘤继发的BRAF突变型组织细胞/树突状细胞肿瘤向高级别B细胞淋巴瘤转化并对此前BRAF/MEK抑制剂治疗产生耐药的病例报告
Claire Royer-Chardon,Bettina Bisig,Mounir Trimech et al.
Claire Royer-Chardon et al.
Transdifferentiation from follicular lymphoma (FL) to histiocytic/dendritic cell sarcoma (HDS) is rare and requires molecular confirmation of shared clonal origin. Targetable mutations such as BRAF V600E may offer therapeutic opportunities ...
Triple-negative breast cancer: a threshold-defined diagnostic category within a biological continuum [0.03%]
三阴性乳腺癌：一个在生物学连续谱中的门槛式诊断类别
Emad A Rakha
Emad A Rakha
Triple-negative breast cancer (TNBC) is defined in routine practice by the absence of oestrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor 2 (HER2) expression using fixed immunohistochemical and in ...
Diagnostic yield and cost of three-level H&E sectioning in prostate biopsies [0.03%]
三水平HE染色在前列腺穿刺活检中的诊断价值及成本分析
Ruth Gichinga,Marcos Lepe,Quinn Rainer et al.
Ruth Gichinga et al.
Aim: The traditional three-level H&E sectioning protocol for prostate biopsies was developed for ultrasound-guided systematic sampling and predates lesion-targeted biopsy approaches. Multiparametrical MRI (mpMRI) has impr...