REV7 subunit of mutagenic DNA polymerase ζ as a predictive biomarker for the efficacy of immune checkpoint inhibitor therapy in melanoma [0.03%]
Rev7解旋酶作为黑色素瘤免疫检查点抑制剂疗效预测标志物的研究
Akiyoshi Hoshino,Koya Obara,Masaaki Ichinoe et al.
Akiyoshi Hoshino et al.
Immune checkpoint inhibitor (ICI) therapy serves as a standard treatment for advanced or recurrent malignant melanoma. Tumour neoantigenicity is an important factor for the effectiveness of the ICI therapy. However, the absence of reliable ...
Prognostic value of immunohistochemical markers of intratumoral hypoxia in pregnancy-associated breast cancer [0.03%]
与妊娠相关的乳腺癌中肿瘤内缺氧免疫组化标记物的预后价值
Carsten F J Bakhuis,Paul J van Diest,Britt B M Suelmann et al.
Carsten F J Bakhuis et al.
Aims: Breast cancer (BC) during pregnancy (PrBC) and the postpartum period (PPBC) often exhibits more aggressive tumour characteristics and is associated with a poorer prognosis compared with age-matched nonpregnant patie...
CD31 expression in human cancers: a pan-cancer immunohistochemical study [0.03%]
人癌症中的CD31表达：泛癌免疫组化研究
Ayumi Ito,Yukinobu Ito,Hiroko Ikeda et al.
Ayumi Ito et al.
Aims: CD31 (platelet endothelial cell adhesion molecule 1) is a transmembrane glycoprotein involved in cell adhesion and signal transduction that is primarily expressed in vascular endothelial cells, platelets, neutrophil...
Deep learning predicts microsatellite instability status in colorectal carcinoma in an ethnically heterogeneous population in South Africa [0.03%]
深度学习预测南非种族多样人群中结直肠癌微卫星不稳定性状态
Alessandro Pietro Aldera,Didem Cifci,Gregory Patrick Veldhuizen et al.
Alessandro Pietro Aldera et al.
Background: Deep learning (DL) models are effective pre-screening tools for detecting mismatch repair deficiency (dMMR) in colorectal carcinoma (CRC). These models have been trained and validated on large cohorts from the...
Rare case of CD20-positive primary cutaneous T-cell lymphoma, NOS, with an aggressive clinical course [0.03%]
一例罕见的CD20阳性皮肤T细胞淋巴瘤（非特指型）伴凶险临床经过的病例报告
Danielle R Rinck,Michael S Chang,Christopher Iriarte et al.
Danielle R Rinck et al.
Improving transparency in publishing: gaps in standardised reporting across surgical pathology and laboratory medicine journals [0.03%]
提高发表的透明度：外科病理学和实验医学期刊标准化报告中的差距
Griffin Hughes,Cameron O&#x;Brien,Reece Anderson et al.
Griffin Hughes et al.
Aims: Research reporting checklists are itemised writing standards to improve transparency and facilitate reproducibility. Previous assessments of their recommendation or requirement have demonstrated improved checklist a...
Foundation models in pathology: bridging AI innovation and clinical practice [0.03%]
病理学中的基础模型：连接AI创新与临床实践
Sean Hacking
Sean Hacking
Foundation models are revolutionising pathology by leveraging large-scale, pretrained artificial intelligence (AI) systems to enhance diagnostics, automate workflows and expand applications. These models address computational challenges in ...
SOX17: a new therapeutic target for immune evasion of colorectal cancer [0.03%]
SOX17：一个新的治疗靶点用于结直肠癌的免疫逃逸
Avash Das,Omer Yilmaz,Osman Yilmaz et al.
Avash Das et al.
Despite advances in cancer immunotherapies across various cancers, survival outcomes in colorectal cancer (CRC) with these agents remain largely unsatisfactory despite the high tumour burden. Colorectal stem cells (CSCs), especially LGR5+ C...
Fifth edition WHO classification: precursor lymphoid neoplasms, acute leukaemias of mixed or ambiguous lineage, myeloid/lymphoid neoplasms, and histiocytic and dendritic cell neoplasms, including strategies for application in resource-limited settings [0.03%]
第五版WHO分类：淋巴母细胞病变、混合或起源不明急性白血病、髓系/淋系肿瘤及组织细胞和树突状细胞肿瘤的诊断策略，包括在医疗资源有限情况下的应用
Prashant Tembhare,Xueyan Chen,John K C Chan et al.
Prashant Tembhare et al.
The fifth edition of the WHO classification of haematolymphoid tumours (WHO-HEM5) introduces significant updates to the classification of acute lymphoblastic leukaemia, ALAL (including mixed phenotype acute leukaemia (MPAL)), myeloid/lympho...
GLI1 amplification and fusion in MDM2-amplified low-grade osteosarcoma [0.03%]
低级别骨肉瘤中MDM2扩增肿瘤的GLI1扩增和融合现象
Lan Li,Ming Zhang,Xiaoqi Sun et al.
Lan Li et al.
Aims: Glioma-associated oncogene homologue 1 (GLI1) was recently shown to be coamplified with mouse double minute 2 (MDM2), cyclin-dependent kinase 4 (CDK4) and some other adjacent genes in a significant subset of GLI1-al...