Devahuti R Chaliha,Virginie Lam,Arazu Sharif et al.
Devahuti R Chaliha et al.
In this opinion, we propose that compromised microvascular perfusion and inflammation are fundamental drivers of chronic pain syndromes, with many of these conditions sharing a common etiology involving suboptimal blood flow and inflammator...
The overlooked uterine factor: unlocking endometrium potential in premature ovarian insufficiency [0.03%]
被忽视的子宫因素——卵巢早衰中子宫内膜潜力的开发
Zhonghong Zeng,Dan Mo,Yusong Liu et al.
Zhonghong Zeng et al.
To date, research on premature ovarian insufficiency (POI) primarily centers on ovarian dysfunction and systemic hormonal imbalances, with limited attention given to associated endometrial alterations. Given the critical role of the endomet...
Repurposing of microbial proteins as new-generation therapeutic agents for biomedical applications [0.03%]
微生物蛋白的再利用作为新一代生物医学应用治疗剂
Sivapriya Pavuluri,Rajesh Kotcherlakota,Sangita Mukhopadhyay
Sivapriya Pavuluri
Microbial pathogens have developed diverse strategies to exploit the host immune system because of their long period of coevolution with the target hosts. A deeper understanding of these mechanisms, particularly the role of microbial virule...
Maria Petricǎ,Marisa Ferreira-Marques,Rodrigo F N Ribeiro et al.
Maria Petricǎ et al.
The hypothalamus is a central regulator of circadian rhythms, metabolism, and endocrine function, integrating internal and external cues to maintain physiological homeostasis. Aging impairs hypothalamic function, leading to metabolic change...
Davide Giuseppe Ribaldone,Giulia Valdiserra,Clelia Di Salvo et al.
Davide Giuseppe Ribaldone et al.
Despite revolutionary molecular targeting therapies introduced over the past two decades for the management of inflammatory bowel disease (IBD), there remains significant variability in drug efficacy, which likely reflects the multifactoria...
Gen Li,Linling Cheng,Io Nam Wong et al.
Gen Li et al.
Aging is the gradual decline in physiological function essential for survival and reproduction. Unlike age-associated diseases, aging affects all individuals within a species, causing progressive impairments across multiple systems. Researc...
Tryptophan metabolites at the service of neuroimmune sensing of microbes [0.03%]
色氨酸代谢产物在神经免疫微生物感应中的作用
Ying Wang,Jiajie Li,Zhengqi Lian et al.
Ying Wang et al.
Hosts have evolved multifaceted, intricate mechanisms to sense and respond to the microbes they coexist with, and these mechanisms play an important role in health and disease. The co-metabolism of dietary components by hosts and their micr...
Nobuhiko Kanaya,Khalid Shah
Nobuhiko Kanaya
Leptomeningeal metastasis (LM) represents a devastating and terminal complication of advanced solid tumors, characterized by the dissemination of malignant cells within the leptomeninges and cerebrospinal fluid. Conventional therapies have ...
Sara Young,Kelly Davidson,William A Petri Jr
Sara Young
Iron, regulated by the hormone hepcidin, is essential for cellular function and diverse biological processes. In this forum, we examine emerging therapeutic approaches targeting the hepcidin-iron axis, with applications across three key are...
Manuela Basso,Caterina Marchioretti,Simona Zito et al.
Manuela Basso et al.
Men have a higher incidence of specific types of cancer and neurodegenerative disease. Mounting evidence suggests that androgen receptor (AR)-mediated androgen signaling is a key determinant at the core of this sex discrepancy. Herein we re...