Michaela M Meehl,Meghan B Ward,Giedre Krenciute
Michaela M Meehl
Single cell RNA sequencing (scRNA-seq) has revolutionized the field of biology and become the most powerful tool for evaluating transcriptional profiles of a biological sample. Given its power, it is widely utilized across multiple discipli...
Isabel Fuster-Martínez,Vanesa Bernal-Monterde,Guillaume Bidault et al.
Isabel Fuster-Martínez et al.
The liver has a unique microarchitecture, with hepatic sinusoids receiving blood from the portal vein and hepatic artery and draining into the central vein. This flow establishes an oxygen gradient along the sinusoids critical for defining ...
Polycystic kidney disease [0.03%]
多囊肾病
Sara Clerici,Alessandra Boletta
Sara Clerici
Major depressive disorder: susceptibility, underlying mechanisms, and emerging therapies [0.03%]
抑郁症：易感性、潜在机制及新兴疗法
Anna Onisiforou,Morfeas Koumas,Panos Zanos
Anna Onisiforou
Jillian Stark,Jia-Shu Yang,Victor W Hsu et al.
Jillian Stark et al.
Palma et al. show that melanoma cells adapt to oxidative stress imposed by the lymphatic niche by shifting their dependency from glutathione peroxidase 4 (GPX4) to ferroptosis suppressor protein 1 (FSP1), to protect from ferroptosis. This h...
GLP-1 agonists in neurodegeneration: a multimodal biomarker-guided approach [0.03%]
GLP-1受体激动剂在神经退行性疾病治疗中的应用：多模态生物标志物引导的策略
Jose A Santiago,Jean C Gutierrez-Silva,Wei-Chuan Hsu et al.
Jose A Santiago et al.
Glucagon-like peptide-1 receptor agonists (GLP1-RAs), widely used for type 2 diabetes mellitus, are emerging as promising neuroprotective therapies in Alzheimer's disease (AD) and Parkinson's disease (PD). Agents such as exenatide, lixisena...
Neil A Roberts,Melanie M Y Chan,Adrian S Woolf
Neil A Roberts
Congenital urinary bladder outflow obstruction (BOO) is a major cause of kidney failure in children. Sometimes, it is caused by anatomical obstruction of the urethra. In other cases, functional failure of voiding occurs without anatomical o...
Naomi Okugbeni,Victoria Cole,Elouise Kroon et al.
Naomi Okugbeni et al.
Tuberculosis (TB) remains a major global health burden, prompting heightened efforts towards host-directed therapies (HDT). Autophagy, a key antimicrobial and immunomodulatory process, is a promising candidate for HDT. However, despite enco...
Jan-Bernd Funcke,Philipp E Scherer,Leon G Straub
Jan-Bernd Funcke
Lijun Zhao,Rui Zheng,Wenyue Liu et al.
Lijun Zhao et al.
Immunotherapy resistance, orchestrated largely by the tumor microenvironment, remains a major clinical challenge. Recent advances highlight metabolic reprogramming as a key driver of this resistance. In this review we focus on cholesterol m...