Decoding atopic dermatitis: pathophysiology, clinical diagnosis, and treatments [0.03%]
特应性皮炎：病理生理、临床诊断和治疗
Gowtham Subramanian,Wei Jun Lam,Elizabeth Huiwen Tham et al.
Gowtham Subramanian et al.
Zirui Zhu,Jocelyn Mathew,Benjamin Barrett et al.
Zirui Zhu et al.
Intercepting cancer development with immune-modulating approaches before cancer has established is an emerging and promising strategy to reduce the global cancer burden. By safely harnessing the immune system, cancer vaccines can enhance im...
Wei Wang,Ling Shan,Fang Han
Wei Wang
Itamar C G Jesus,Julio C B Ferreira
Itamar C G Jesus
A recent study by Angelino et al. uncovered an intracellular signaling pathway involved in musculoskeletal mitochondrial dysfunction in cancer cachexia. Both humans and mice with cancer cachexia display impaired 3',5'-cyclic adenosine monop...
Decoding GPX4 regulation in ferroptosis: mechanisms and therapeutic implications [0.03%]
铁死亡中GPX4调控机制的解析及治疗意义探讨
Xin Chen
Xin Chen
Ferroptosis, a regulated form of cell death, is determined by iron-dependent lipid peroxidation. A selenoenzyme called glutathione peroxidase 4 (GPX4) detoxifies phospholipid hydroperoxides at the heart of this process. As the pivotal gatek...
Zhihui Li,Jiang-Fan Chen
Zhihui Li
A groundbreaking study by Yue et al. reveals adenosine signaling as the convergent mechanism underlying the rapid antidepressant effects of both ketamine and electroconvulsive therapy. This discovery not only resolves a longstanding mechani...
Jiaxin Yan,Wenhui Wang,Gaofei Wei
Jiaxin Yan
Cachexia and hypercalcemia frequently complicate advanced renal cancer. A recent Nature Medicine study by Abu-Remaileh et al. shows that pharmacologic hypoxia-inducible factor 2 (HIF2) inhibition rapidly suppresses parathyroid hormone-relat...
Lucia Minarrieta,Julie St-Pierre
Lucia Minarrieta
In recent years, numerous studies have highlighted the crucial role of mitochondrial metabolism in cancer progression. This sparked interest in its potential as a target for cancer therapy and prompted the clinical evaluation of multiple dr...
Roy Maimon
Roy Maimon
Huntington's disease (HD) is usually described as rare, tragic, and intractable. Yet, HD offers a strategically unique entry point for neuroscience. With its genetic clarity, relatively predictable course, and organized global community, HD...
Stratification of immunotherapy responses by adaptive immune receptor repertoires [0.03%]
适应性免疫受体文库谱系的免疫治疗反应效果分类
Bálint Biró,Mara A Llamas-Covarrubias,Ayan Sengupta et al.
Bálint Biró et al.
A growing number of diseases are now treated with immunotherapies, which consist of interventions that suppress or stimulate the patient's immune system. Because individual humans express a unique repertoire of adaptive immune receptors, th...