Muscle-to-CNS signaling in physiological homeostasis, aging, and disease [0.03%]
肌肉到中枢神经系统的信号传导在生理稳态、衰老和疾病中的作用
Chia-Lung Chuang,Mamta Rai,Fabio Demontis
Chia-Lung Chuang
The central nervous system (CNS) orchestrates homeostatic responses and organismal behaviors by integrating cues from the whole body. Like other peripheral tissues, skeletal muscle can signal to the brain, and this occurs via muscle-secrete...
Platelet-derived and platelet secretome biotherapies for precision neuromedicine [0.03%]
基于血小板衍生和血小板分泌组的精准神经医学生物疗法
Ming-Li Chou,David Blum,Fabrice Cognasse et al.
Ming-Li Chou et al.
Platelet-derived biotherapies are emerging as innovative approaches for complex neurological disorders requiring multimodal interventions. Platelet-derived products, including lysates, platelet concentrate supernatants, secretome, extracell...
Luis A Garza,Yingchao Xue,Ru Dai et al.
Luis A Garza et al.
Mechanical forces regulate development, homeostasis, and repair in the skin, lung, and cornea-external barrier organs that are exposed to stretch, shear, and stiffness. Dysregulated mechanotransduction drives fibrosis, inflammation, and imp...
Cancer mtDNA mutations: metabolic plasticity and therapeutic promise? [0.03%]
癌症线粒体 DNA 突变：代谢可塑性和治疗前景？
Ersong Shang,Omar Aftab,Abbienaya Dayanamby et al.
Ersong Shang et al.
Mitochondria, once viewed mainly as cellular powerhouses, are now recognised as key regulators of cancer metabolism, redox balance, and immune interactions. While early models emphasised a switch to aerobic glycolysis, many tumours exhibit ...
Sterre H T Wouda,Sem Geertsema,Harry van Goor et al.
Sterre H T Wouda et al.
An intact gut barrier is crucial to human health. Functional assessment of gut barrier function and permeability in humans is laborious and demanding. Blood-based biomarkers that reflect gut barrier integrity have gained increasing attentio...
Sun-Wei Guo,Michel Canis,Paolo P Vercellini
Sun-Wei Guo
Whether endometriosis is a progressive disease remains debated. Central to this debate is understanding the natural history of endometriotic lesions, which are essentially wounds undergoing repeated tissue injury and repair. Viewing the dis...
Víctor Núñez-Quintela,Han Li,Manuel Collado
Víctor Núñez-Quintela
Aging, once viewed as an irreversible process, is now considered a modifiable process. Recent advances in cellular reprogramming reveal that transient expression of reprogramming factors can reverse molecular hallmarks of aging while preser...
Targeting endoplasmic reticulum stress and nitroso-redox imbalance in cancer progression [0.03%]
靶向内质网应激和亚硝基化-红氧平衡在癌症进展中的作用
Himanshu Arora,Rehana Qureshi
Himanshu Arora
Therapy-resistant cancers exploit cellular stress programs to survive. Evidence from neuroendocrine prostate cancer reveals that the loss of nitric oxide-dependent redox signaling amplifies endoplasmic reticulum stress and lineage plasticit...
Phage therapy in oncology: opportunities for cancer prevention and treatment [0.03%]
噬菌体治疗在肿瘤学中的应用：癌症预防和治疗的机会
Vivek K Mutalik,Jamie L Inman,Hang Chang et al.
Vivek K Mutalik et al.
Bacteriophages (phages) are emerging as programmable biological therapeutics in oncology, extending beyond their traditional antimicrobial applications. This review proposes a phage-microbiome-immune-oncology axis that links microbial dynam...
Sung Woo Kim,Alper Genceroglu,Jonghwan Kim
Sung Woo Kim
The placenta is an essential organ that supports fetal development during pregnancy. The establishment of human trophoblast stem cells has enhanced our understanding of placental development; however, their limited diversity constrains our ...