β-hydroxybutyrate supplementation boosts the tumor-killing potential of CAR T cells [0.03%]
β-羟丁酸补充可增强CAR-T细胞的肿瘤杀伤潜能
Christos Adamopoulos,Kostas A Papavassiliou,Athanasios G Papavassiliou
Christos Adamopoulos
In a recent study in Cell, Liu et al. identify β-hydroxybutyrate as a practical metabolic adjuvant for CAR-T cells. By fueling the TCA cycle and reshaping transcriptional and epigenetic programs, this ketone body enhances proliferation, pe...
Georgia Zancotti,Gisela Weiz,Cyrollah Disoma et al.
Georgia Zancotti et al.
Hepatocellular carcinoma (HCC) remains a major global health challenge, with rising incidence, frequent development of drug resistance, and limited long-term survival despite advances in systemic therapies. Within the tumor microenvironment...
Alexandra Y Kreins,Katja G Weinacht
Alexandra Y Kreins
The function of the thymus, essential for T cell development, declines sharply with age. Genetic defects that disrupt thymic organogenesis or function lead to profound immunodeficiency and autoimmunity. Allogeneic thymus transplantation for...
Yingying Yu,Yizhou Lu,Xuexian Fang
Yingying Yu
Ferroptosis, an iron-dependent form of regulated cell death, is increasingly recognized as a key mechanism in disease pathogenesis and treatment. As essential biomedical models, mice have played an instrumental role in uncovering the relati...
Senescent Schwann cells as therapeutic targets in nerve regeneration and peripheral neuropathies [0.03%]
衰老施万细胞在神经再生和外周神经病中的治疗作用
Daniela L Rebolledo,Maaz Khan,Simon Melov et al.
Daniela L Rebolledo et al.
Peripheral nerve regeneration declines with aging and prolonged denervation, yet the underlying mechanisms have remained elusive. Recent studies identify senescent Schwann cells (senSCs) as a key contributor. Following injury, repair Schwan...
Could venom-derived therapeutics resolve treatment resistance in refractory EAC? [0.03%]
毒液衍生的治疗能否解决难治性食管腺癌(EAC)的治疗抵抗问题？
Lou Freuville,Chloé Matthys,Quentin Gilliaux et al.
Lou Freuville et al.
The incidence of esophageal adenocarcinoma is rising in Western countries. Despite advances in chemotherapy and immunotherapy, the prognosis remains poor, with an overall 5-year survival rate below 15%. A major challenge is the cancer's poo...
Pingxin Sun,Chao Wang,Wenlin Li
Pingxin Sun
Yuan et al. present a novel method for expanding adult human hepatocytes and assembling them with cholangiocytes and portal fibroblasts into patient-specific periportal liver assembloids. This system recapitulates liver architecture and fun...
Junlin Wei,Fang Wang
Junlin Wei
Satellite glial cells transfer mitochondria to sensory neurons via myosin 10-dependent tunneling nanotubes. Ji et al. show that this transfer is impaired in diabetic neuropathy, causing energy failure. Restoring it via cell or mitochondrial...
Dorra Elhaj Mahmoud,Benoit Briard,Nicolas Papon
Dorra Elhaj Mahmoud
Invasive candidiasis is a severe fungal infection with management challenges due to a lack of biomarker-guided patient stratification and limited availability of antifungal drugs. Liu et al. identified the cytokine Meteorin-like as a key re...
Harnessing the lung microbiome for precision management of fibrotic lung disease [0.03%]
利用肺部微生物组进行纤维化性肺病的精准管理
Sylvie Leroy,Barnabé Roméo,Amine Belaid et al.
Sylvie Leroy et al.
Interstitial lung diseases, particularly idiopathic pulmonary fibrosis (IPF), have dismal prognoses, with a median survival of 3-5 years, owing to a lack of early biomarkers or effective treatments. This review highlights the lung microbiom...