Tumor microenvironment and metabolic reprogramming in MASLD-related hepatocellular carcinoma [0.03%]
代谢重塑和肿瘤微环境在非酒精性脂肪肝病相关肝细胞癌中的作用
Vanilla X Zhang,Tiffany C-Y Yu,Yu M Tsui et al.
Vanilla X Zhang et al.
Metabolic dysfunction-associated steatotic liver disease (MASLD) has become one of the leading causes of hepatocellular carcinoma (HCC), yet the mechanisms of tumor microenvironment (TME)-metabolic crosstalk remain incomplete. This review s...
Molecular basis and clinical implications of TANGO2 deficiency disorder [0.03%]
TANGO2缺陷紊乱的分子基础与临床意义
Ombretta Foresti,Agustin L Lujan
Ombretta Foresti
TANGO2 deficiency disorder (TDD) is an ultrarare, autosomal recessive disease characterized by neuromuscular impairment, intellectual disability, and recurrent metabolic crises leading to life-threatening ventricular arrhythmias. Intrafamil...
Rhythms in your bones: how circadian rhythms impact bone cell function and skeletal health [0.03%]
骨髓中的节奏：昼夜节律对骨细胞功能和骨骼健康的影响
Cansu Gorgun,Ronan Lordan,Oran D Kennedy et al.
Cansu Gorgun et al.
Circadian rhythms play a central role in how bone tissue is formed, resorbed, and remodelled during the 24-h cycle. Bone cells express core clock proteins, which coordinate the timing of these processes, each contributing differently to the...
Marta Cimadevila,Carlos Matute
Marta Cimadevila
Myelination is increasingly recognized as a dynamic and adaptive process regulated by oligodendrocytes throughout life. Beyond providing electrical insulation, myelin supports axonal metabolism and may serve as an energy reservoir under met...
Shokrollah Elahi
Shokrollah Elahi
Long COVID may reflect a failure of coordinated physiological recovery rather than persistent infection. Emerging evidence identifies inflammation-driven disruption of erythropoiesis and hormonal balance as central mechanisms linking immune...
Md Ibrahim,Md Shahadat Hossain,Lezanne Ooi et al.
Md Ibrahim et al.
Amyotrophic lateral sclerosis (ALS) remains a fatal neurodegenerative disease with few effective therapies. Emerging evidence indicates that oxidative DNA damage, defective base excision and single-strand break repair, and progressive NAD+ ...
Fabio Marcheggiani,Ilaria Nunzi,Loredana Rao et al.
Fabio Marcheggiani et al.
Mitochondria are central regulators of cerebrovascular health through their control of energy metabolism, Ca2+ homeostasis, and redox signaling, and their dysfunction represents a convergent pathogenic mechanism across cerebrovascular disea...
Epigenetic remodeling after viral pneumonia accelerates lung tumorigenesis [0.03%]
病毒性肺炎后的表观遗传重编程加速肺肿瘤发生
Weici Laurence Liu,Zheshun Pi,Peng Luo et al.
Weici Laurence Liu et al.
Previous epidemiological studies have associated viral pneumonia with an increased risk of lung cancer. Recently, Qian et al. revealed that epigenetic reprogramming following respiratory viral infections accelerates tumorigenesis by orchest...
Karin Byskata,Sofia Bartholdsson,Sara Gredmark-Russ
Karin Byskata
Joel C Watts,Christina J Sigurdson,Debbie Yobs et al.
Joel C Watts et al.
Neurodegenerative dementias are debilitating diseases that include Alzheimer's disease (AD) and AD-related dementias (ADRDs). Creutzfeldt-Jakob disease (CJD) is a rapidly progressive dementia caused by the accumulation of prions in the brai...