Dimitra Gialama,Martin Metz,Pavel Kolkhir
Dimitra Gialama
Stacia P A Everts,Michael Florea,João Pedro de Magalhães
Stacia P A Everts
Aging affects virtually all organs and biological processes, and age-related diseases remain the leading causes of death worldwide. Genetic factors play a central role in modulating lifespan, and discoveries in the genetic manipulation of t...
Xavier Palomer,Ricardo Rodríguez-Calvo,Sandra García-Mateo et al.
Xavier Palomer et al.
Primary biliary cholangitis (PBC) is a chronic cholestatic liver disease characterized by autoimmune-mediated destruction of intrahepatic bile ducts, leading to fibrosis, cirrhosis, and liver failure. Ursodeoxycholic acid remains the first-...
Mei Feng,Alessandro Granito
Mei Feng
Hepatocellular carcinoma (HCC) arises within an immunologically complex, tolerogenic microenvironment, where CD4+ CD25+ Foxp3+ regulatory T cells (Tregs) suppress antitumor immunity, sustain inflammation, and promote pathological angiogenes...
Converging signalling disruptions: a threshold for Down syndrome hearts [0.03%]
信号干扰趋同：21三体综合征心脏的阈值问题
Mariel Schwietzer,Holger Reinecke,Rinesh Godfrey
Mariel Schwietzer
Why do half of all children with Down syndrome have heart defects? Recent studies show that multiple chromosome 21 genes-most notably the chromatin regulator high-mobility group nucleosome-binding domain 1-collectively disrupt bone morphoge...
Deubiquitinases at organelle quality control bottlenecks in neurodegeneration [0.03%]
神经变性障碍中细胞器质量控制瓶颈处的去泛素酶的作用
Lisa M Ellerby,Avraham Ashkenazi
Lisa M Ellerby
Neurodegenerative diseases with prominent motor symptoms converge on mitochondrial and lysosomal bottlenecks in selectively vulnerable neurons. Deubiquitinases regulate ubiquitin-dependent organelle fate at these decision points. Emerging e...
Nicla Lorito,Francesca Bonechi,Elisabetta Romano et al.
Nicla Lorito et al.
Therapy resistance is a major obstacle to durable clinical responses. While genetic alterations and signalling rewiring are primary drivers of resistance, metabolic adaptation, which is closely intertwined with these processes, enables tumo...
Zhiqi Liao,Linghui Wang,Gordon B Mills et al.
Zhiqi Liao et al.
Most solid tumors remain immunologically 'cold' and refractory to therapy, making immunogenic cell death (ICD) induction a central therapeutic goal. Z-DNA binding protein 1 (ZBP1) acts as a sensor, converting intrinsic nucleic acid stress i...
Lipodystrophy syndromes: when the absence of adipose tissue rewires whole-body metabolism [0.03%]
脂代谢综合征：脂肪组织缺失如何重塑全身代谢
Rugivan Sabaratnam,Kurt Højlund
Rugivan Sabaratnam
Candice Roufosse,Omar Bouricha,Alana Burrell et al.
Candice Roufosse et al.
Immune cells mediate acute and chronic renal failure in native and transplanted kidneys, initiating auto- and allo-immunity, and acting as effectors in other diseases such as diabetes, hypertension, and cancer. Many drugs already in use or ...