Ubiquitin-specific peptidase 22 targeting: Tumor cell erasure, immune engine unleashed [0.03%]
泛素特异性蛋白酶22靶向：肿瘤细胞消除，免疫引擎释放
Deyu Fang
Deyu Fang
Deubiquitinases regulate key oncogenic and immune pathways but have proven challenging to exploit therapeutically. Among them, ubiquitin-specific protease 22 (USP22) has emerged as a molecule of interest due to its involvement in both tumor...
Canhui Cao
Canhui Cao
Neuroimmune circuits are emerging as a critical layer of host defense. Recent studies show that sensory neurons shape interferon responses, myeloid dynamics, and T cell priming during viral infection, while viruses reprogram these circuits ...
Jiayu Li,Quazi T H Shubhra,Xiaojun Cai
Jiayu Li
Hyocholic acids (HCAs), synthesized by fetal CYP3A7, dominate the neonatal bile acid pool. By promoting regulatory T cells and suppressing T helper 17 cells, HCAs establish intestinal immune tolerance, guide healthy microbiota assembly, and...
Clonal hematopoiesis in Alzheimer's brain: Protective, pathogenic, and context-dependent? [0.03%]
阿尔茨海默病大脑中的克隆性血液细胞：保护作用、致病作用还是取决于环境因素？
Hong Zhao,Katherine Y King,Stephen T Wong
Hong Zhao
Clonal hematopoiesis is emerging as a surprising modifier of Alzheimer's disease. Recent findings suggest that mutant myeloid cells may enter or expand within the brain, adopting either inflammatory or reparative states. We propose that the...
Yibing Wu,Carmen Chak-Lui Wong
Yibing Wu
Hepatocellular carcinoma (HCC) remains lethal due to its high refractoriness to standard treatment, which is contributed to by factors including adaptive metabolic reprogramming of HCC cells and pre-existing liver diseases that compromise l...
Yajing Wang,Usama Ahmad,Xiaojun Cai et al.
Yajing Wang et al.
By identifying graft ferroptosis as a druggable vulnerability, Veeckmans et al. show that FXT-001 intercepts lipid-radical injury during machine perfusion and improves liver and lung graft function. This work supports rather than proves mac...
Luigi Racioppi
Luigi Racioppi
Tumor progression depends on coordinated adaptation of cancer cells and the tumor microenvironment to immune pressure, metabolic limitations, genomic instability, and biomechanical stress. While these adaptive responses have often been inve...
Tongtong Cui,Bojin Li,Bingyu Cai et al.
Tongtong Cui et al.
Gene therapy is evolving from gene addition to precise genome editing, enabling the direct correction of disease-causing mutations. Breakthrough technologies, such as clustered regularly interspaced short palindromic repeats-CRISPR-associat...
Chunheng Mo
Chunheng Mo
Ischemia-reperfusion injury accelerates graft deterioration and limits the use of marginal donor organs. Recently, Veeckmans et al. showed that pharmacological ferroptosis inhibition preserves liver and lung graft function across porcine an...
Amyotrophic lateral sclerosis: A rare but aggressive adult-onset disease [0.03%]
肌萎缩侧索硬化：一种罕见但凶险的成人发病疾病
Luca Brodribb,Phil Camden,Thanuja Dharmadasa et al.
Luca Brodribb et al.