Luis Varela,Tamas L Horvath
Luis Varela
Melanocortin receptors play crucial roles in multiple physiological processes. Melanocortin receptor 4 (MC4R) is expressed in key brain regions, and MC4R gene mutations can cause severe obesity. However, the cellular biology of MC4R is less...
Erratum to 'Gene therapy for neurodegenerative diseases' [Trends in Molecular Medicine 21 (2015) 504-512] [0.03%]
关于”用于神经退行性疾病的基因治疗“的勘误修正通知(Trends in Molecular Medicine，2015, 21(7):504-512)
Deirdre M O&#x;Connor,Nicholas M Boulis
Deirdre M O&#x;Connor
Published Erratum
Trends in molecular medicine. 2016 Mar;22(3):266. DOI:10.1016/j.molmed.2015.12.008 2016
A New Chapter in Genetic Medicine: RNA Editing and its Role in Disease Pathogenesis [0.03%]
基因医学新篇章：RNA编辑及其在疾病发生发展中的作用
Khatuna Gagnidze,Violeta Rayon-Estrada,Sheila Harroch et al.
Khatuna Gagnidze et al.
The transfer of genomic information from DNA to mRNA to protein usually occurs with high fidelity, but can also be subverted by a programmed RNA sequence alteration termed 'RNA editing', involving deamination of adenosine to inosine (decode...
Macrophages Remember Cheeseburgers and Promote Inflammation via NLRP3 [0.03%]
巨噬细胞“记得”炸薯条和 cheeseburger 并通过 NLRP3 促进炎症
Luke A J O&#x;Neill,Zbigniew Zaslona
Luke A J O&#x;Neill
In a recent study, Christ and colleagues identify a key role for NLRP3/IL-1beta in the induction of innate immune memory in monocytes by the Western diet, promoting atherosclerosis and inflammatory diseases. ...
NEMO Links Nuclear Factor-κB to Human Diseases: (Trends Mol Med. 23, 1138-1155; 2017) [0.03%]
核因子κB与人类疾病之间的联系：NEMO Tales（《 Trends in Molecular Medicine》第23卷，第1138–1155页，2017年）
Gunter Maubach,Ann-Christin Schmädicke,Michael Naumann
Gunter Maubach
Published Erratum
Trends in molecular medicine. 2018 Jul;24(7):654. DOI:10.1016/j.molmed.2018.01.009 2018
Amanda Kallen,Alex J Polotsky,Joshua Johnson
Amanda Kallen
Even with the benefit of assisted reproductive technologies (ART), many women are unable to conceive and deliver healthy offspring. One common cause of infertility is the inability to produce eggs capable of contributing to live birth. This...
Ivano Luigi Colao,Randolph Corteling,Daniel Bracewell et al.
Ivano Luigi Colao et al.
Extracellular vesicles, in particular the subclass exosomes, are rapidly emerging as a novel therapeutic platform. However, currently very few clinical validation studies and no clearly defined manufacturing process exist. As exosomes progr...
Gayatri Arun,Sarah D Diermeier,David L Spector
Gayatri Arun
Long non-coding RNAs (lncRNAs) represent a significant population of the human transcriptome. Many lncRNAs exhibit cell- and/or tissue/tumor-specific expression, making them excellent candidates for therapeutic applications. In this review ...
In Vivo Imaging of Single Mammalian Cells in Development and Disease [0.03%]
发育和疾病条件下活体哺乳动物单细胞的体内成像技术研究
Melanie D White,Ziqing W Zhao,Nicolas Plachta
Melanie D White
Live imaging has transformed biomedical sciences by enabling visualization and analysis of dynamic cellular processes as they occur in their native contexts. Here, we review key recent efforts applying in vivo optical imaging with single-ce...
Vijay A K Rathinam,Francis Ka-Ming Chan
Vijay A K Rathinam
Organismal fitness demands proper response to neutralize the threat from infection or injury. At the mammalian intestinal epithelium barrier, the inflammasome coordinates an elaborate tissue repair response marked by the induction of antimi...