Samet Agca,Serkan Kir
Samet Agca
Bhatt et al. have identified two RNAome-based skeletal muscle subtypes in cancer cachexia. The first subtype is cachexia associated with weight and muscle loss, fiber atrophy, and shortened survival. Furthermore, this subtype has dysregulat...
Ren Zhang
Ren Zhang
The angiopoietin-like protein (ANGPTL)3/8 complex regulates triglyceride partitioning, and its selective blockade lowers triglycerides while raising HDL-cholesterol (HDL-C). Clinical and genetic evidence support ANGPTL3/8 antagonism as a pr...
Morgan Robinson,Kyle Wettschurack,Manasi S Halurkar et al.
Morgan Robinson et al.
Precision medicines for monogenic brain disorders are rapidly advancing. Voltage-gated sodium channel (VGSC) genes are the leading monogenic cause of severe epilepsy and profound autism spectrum disorder (ASD), most notably SCN1A, SCN2A, SC...
Ting Xu,Kun Fu,Chao Ma et al.
Ting Xu et al.
Emerging evidence highlights the brain renin-angiotensin system (RAS) as a key regulator of reward, memory, and stress. While these discoveries established the brain RAS as a promising therapeutic target for interventions in neurological an...
Programmable lipid nanoparticle tropism unlocks precision RNA medicine [0.03%]
可编程脂质纳米颗粒靶向性解锁精准RNA药物疗法
Usama Ahmad,Robert Musiol,Xiaojun Cai et al.
Usama Ahmad et al.
Peptide-ionizable lipids (PILs) establish a rational design paradigm for RNA delivery, defining a chemical code that programs organ tropism and enables systemic prime editing. By achieving precise mRNA and genome editing beyond the liver, t...
Gengyun Le-Chan,Sunny S K Chan,Cindy A Thomas-Charles et al.
Gengyun Le-Chan et al.
Hyaluronan synthases (HASs) are essential enzymes for hyaluronic acid (HA) production; a key component for joint lubrication and cartilage health. Dysregulated HA synthesis contributes to joint dysfunction. In this Forum, we discuss the rol...
Integrator 20th anniversary: a molecular machine indispensable in development and disease [0.03%]
整合子二十年：发育和疾病中不可或缺的分子机器
Mina M Tayari,Ramin Shiekhattar
Mina M Tayari
The Integrator complex, composed of at least 19 subunits, associates with RNA polymerase II (RNAPII) and exerts critical roles in transcriptional regulation. By interacting with the C-terminal domain (CTD) of RNAPII, it cleaves nascent RNA ...
Ziad Al Nabhani
Ziad Al Nabhani
In a recent Science study, Shenoy et al. reveal that maternal milk IgG programs neonatal immunity in mice. During the first postnatal week, IgG forms complexes with gut microbes, calibrating T cell responses at weaning and establishing long...
Shenglong Xia,Dingjiacheng Jia,Liangjing Wang
Shenglong Xia
Metastasis remains a major contributor to the poor prognosis for patients with cancer, primarily driven by dynamic interactions between cancer cells and the tumor microenvironment. Accumulating evidence highlights the pivotal involvement of...
Anti-N-methyl-d-aspartate receptor encephalitis: insights and future treatment directions [0.03%]
抗N-甲基-D天冬氨酸受体脑炎：认识和未来治疗方向
Yoji Hoshina,Tammy L Smith,Melissa A Wright et al.
Yoji Hoshina et al.
Two decades after the first recognition of anti-N-methyl-d-aspartate receptor (NMDAR) encephalitis, advances have led to consensus-based diagnostic criteria and treatment recommendations, yet no FDA-approved therapies exist. Recent studies ...