Nathan M Johnson,Monique E Hinchcliff,Ian D Odell
Nathan M Johnson
Liang Cao,Rui Zhang,Yanjun Zhang et al.
Liang Cao et al.
Ferroptosis has emerged as a critical contributor to secondary brain injury in cerebrovascular diseases (CVDs). However, the clinical translation of antiferroptotic therapies remains stalled because current strategies often treat CVDs as a ...
Cindy A Thomas-Charles,Raymond Xue,Amara R Agosto et al.
Cindy A Thomas-Charles et al.
Cartilage is susceptible to degeneration from injury, overuse, or age-related wear. Articular cartilage, the smooth hyaline cartilage covering the ends of bones in synovial joints, has limited intrinsic repair capacity because its avascular...
Md Jashim Uddin,Jocelyn King,Christopher C Broder et al.
Md Jashim Uddin et al.
Rabies is a lethal acute viral encephalitis caused by neurotropic lyssaviruses, particularly Lyssavirus rabies. The current treatment for rabies exposure involves post-exposure prophylaxis (PEP), which includes the administration of the rab...
Kai Liu,Quazi T H Shubhra,Hui Zhang
Kai Liu
Horizontal mitochondrial transfer (HMT) outcomes are shaped by donor fitness and transfer context. We propose a post-transfer quality checkpoint that integrates membrane potential, oxidative damage, mitophagy, fusion, and fission to determi...
Extracellular vesicle biomarkers in gastric cancer: Opportunities and challenges [0.03%]
胃癌的细胞外囊泡生物标志物：机遇与挑战
Liao Zhang,Chen Huang,Ya-Qian Xu
Liao Zhang
Extracellular vesicles (EVs) are promising liquid biopsy candidates for gastric cancer because they can capture tumor-, immune-, microbial-, and microenvironment-related signals. We argue that the main challenge is no longer simply to find ...
Syed F H Shah,Catherine Y Liao,Edel A O&#x;Toole
Syed F H Shah
A recent study by Cohen et al. identified stress-induced keratin 16 (KRT16) as an active regulator of skin innate immunity. By sequestering 14-3-3ε, KRT16 suppresses retinoic acid-inducible gene I-mediated type I interferon (IFN) signallin...
Siyu Li,Bavid Qiu,Xin Yi et al.
Siyu Li et al.
Ferroptosis is a unique form of programmed cell death that involves multiple organelles. Although traditionally viewed as a 'degradation workshop', accumulating evidence reveals that the lysosome serves as a central hub for iron metabolism ...
Valentina Salsi,Francesca Losi,Gabriella Viero et al.
Valentina Salsi et al.
The nucleolus is a master regulator of ribosome biogenesis and cellular homeostasis, as well as an increasingly key determinant of neuromuscular diseases. Across these conditions, diverse genetic and molecular lesions converge on alteration...
Xu Han,Xiangwei Sun,Qintao Wang et al.
Xu Han et al.
Disorders involving endosomal signaling pathways are gaining attention due to their roles in immune regulation. This review proposes a new disease category, endosomal signaling disorders (ESDs), to describe disorders caused by dysfunction o...