Evaluation of venetoclax and hypomethylating agent combination therapy in acute myeloid leukemia: a real-life, single-center experience [0.03%]
维奈克拉联合低甲基化药物治疗急性髓系白血病的疗效及安全性：一项单中心真实世界研究
Kübra Oral,Ayşe Uysal
Kübra Oral
Aim: The use of venetoclax in combination with hypomethylating agents (HMAs) has become a standard treatment approach for both newly diagnosed and relapsed/refractory (R/R) AML patients who are ineligible for intensive ch...
Study protocol of the C-SOLVE (JACCRO GC-12) trial; a randomized, non-comparative phase II trial of CapeOX or SOX plus zolbetuximab in HER2-negative, CLDN18.2-positive unresectable advanced gastric or esophagogastric junction cancer [0.03%]
C-SOLVE（JACCRO GC-12）研究方案；一项比较卡培他滨联合奥沙利铂或替吉奥与唑普替康在HER2阴性且CLDN18.2阳性不可切除的晚期胃癌或 gastroesophageal junction cancer患者的II期非随机试验
Satoshi Yuki,Hisato Kawakami,Kazuaki Harada et al.
Satoshi Yuki et al.
Background: Capecitabine + oxaliplatin (CapeOX) + zolbetuximab and 5-FU + oxaliplatin (mFOLFOX6) + zolbetuximab are recommended as first-line treatments for chemotherapy-naïve patients with HER2-negative, CLDN18.2-positi...
High-risk human papillomavirus genotypes and associated clinical pathological factors among patients with oropharyngeal squamous cell carcinoma in north-western Tanzania [0.03%]
坦桑尼亚西北部咽鳞癌患者的高危人乳头瘤病毒基因型及其相关临床病理因素
Oscar Ottoman,Fidelis David,Michael James et al.
Oscar Ottoman et al.
Background: Oropharyngeal squamous cell carcinoma (OPSCC) is a significant global health concern, with incidence rising as the prevalence of high-risk human papillomavirus (HPV) increases. Understanding HPV genotypes and ...
Preoperative tumor marker burden score predicts survival in colorectal cancer according to tumor size [0.03%]
术前肿瘤标志物负荷评分可预测结直肠癌患者的生存时间（与肿瘤大小有关）
Dan Tao,Hui He,Jie Chen et al.
Dan Tao et al.
Background: Reliable preoperative biomarkers are needed to improve risk stratification in colorectal cancer (CRC). The prognostic value of a combined score based on multiple serum tumor markers remains underexplored. ...
Efficacy and safety of metronomic oral vinorelbine in elderly patients with locally advanced and metastatic non-small cell lung cancer [0.03%]
小剂量口服长春瑞滨治疗老年局部晚期和转移性非小细胞肺癌患者的疗效及安全性研究
Sharehan Hassan Soliman,Mahinour Mohamed Atef
Sharehan Hassan Soliman
Lung cancer remains one of the most frequently diagnosed malignancies and the leading cause of cancer-related mortality globally. Metronomic chemotherapy (MC) enables prolonged low-dose treatment administration with lower toxicity while mai...
Glioblastoma immune-related gene landscape and its prognostic significance identified with integrative multiomics [0.03%]
整合多组学识别胶质母细胞瘤免疫相关基因谱及其预后意义
Jianbang Han,Linting Luo,Ke Yu et al.
Jianbang Han et al.
Background: Immunotherapy has demonstrated outstanding therapeutic success in solid cancers by regulating immunity through immunological components in the tumor microenvironment. However, the immunological phenotypes and ...
Effectiveness and safety of PD-1/PD-L1 inhibitors plus lenvatinib with or without Gemox chemotherapy in advanced intrahepatic cholangiocarcinoma [0.03%]
抗PD-1/PD-L1单克隆抗体联合仑伐替尼和/或吉玛化疗治疗晚期肝内胆管癌的有效性和安全性
Shuofeng Li,Guanhua Yu,Shanshan Wang et al.
Shuofeng Li et al.
Background and aims: Advanced intrahepatic cholangiocarcinoma (ICC) is characterized by a poor prognosis. This study evaluated the efficacy and safety of programmed cell death protein 1 (PD-1) or programmed death-ligand 1...
Next-generation sequencing-based characterization of BRCA1/2 variants across multiple tumor types in Vietnamese patients [0.03%]
基于下一代测序的越南患者多类肿瘤类型中BRCA1/2变异特征分析
Hong-Thanh Nguyen,Minh-Duc Vu,Dinh-Dung Nguyen et al.
Hong-Thanh Nguyen et al.
Background: Mutations in the BRCA1 and BRCA2 genes play a pivotal role in the pathogenesis of breast, ovarian, prostate, pancreatic, and several other cancers. Identification of these mutations is crucial for selecting pa...
Dosimetric superiority of proton radiosurgery in liver cancer: an in silico comparative dosimetric study [0.03%]
质子放射外科治疗肝癌的剂量学优势：一项基于计算机的比较研究
Jiaran Li,Tao Ma,Hao Zhou et al.
Jiaran Li et al.
Background: This in silico dosimetric study aimed to evaluate a potentially more efficient approach by assessing the dosimetric advantages of single-fraction 35 Gy proton radiosurgery relative to photon therapy. ...
Adjuvant chemotherapy with or without EGFR-TKIs for resected EGFR-mutated non-small cell lung cancer: a pooled analysis of four randomized controlled trials [0.03%]
表皮生长因子受体酪氨酸激酶抑制剂是否可用于表皮生长因子受体突变阳性的早期肺癌患者：四项随机对照研究的汇总分析
Sui Chen,Feilong Guo,Jiafu Zhu et al.
Sui Chen et al.
Background: The role of adding adjuvant epidermal growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) to chemotherapy (ETC) among patients with completely resected EGFR-mutated non-small cell lung cancer (NSCLC)...